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DOE Low Dose Radiation Research
Investigators' Workshop V
Abstracts



Principal Investigator
Abstract Title
Ackerman, Eric

 

Effects of Low Doses of Radiation on DNA Repair
(PNNL Project # 42699)

 

Anderson, Carl W.

 

Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Potential Application to p53 and Low Dose Ionizing Radiation

 

Azzam, Edouard

 

Ionizing Radiation Induced Adaptive Responses in Normal Human Cells Maintained in Three-Dimensional Architecture: the Role of Oxidative Metabolism

 

Azzam, Edouard

 

Radiation-Induced Modulation of Mitochondrial Protein Import Capacity in Normal Human Fibroblasts

 

Bailey, Susan

 

Dysfunctional Mammalian Telomeres in DNA-PKcs Deficient Backgrounds

 

Balmain, Allan

 

Fbxw7/Cdc4 is a p53-dependent haploinsufficient tumour suppressor gene

 

Barcellos-Hoff, Mary Helen

 

A quantitative assessment of bystander mutagenesis in the mouse mammary gland

 

Barcellos-Hoff, Mary Helen

 

Quantitative Assessment of Centrosome Abnormality

 

Bedford, Joel S.

 

Low dose and low dose-rate irradiation for identification of individuals of high, low and intermediate radiosensitivities using the gamma-H2AX assay

 

Bedford, Joel S.

 

Role of Homologous Recombination in the Alpha Particle Bystander Effect for Sister Chromatid Exchanges and Chromosomal Aberrations

 

Blakley, Eleanor

 

X-ray Microbeam Bystander Studies With Human Mammary Epithelial Cells and Fibroblasts

 

Boothman, David

 

Regulatory mechanisms of secretory clusterin (sCLU) expression: a low doseinducible 'bystander' cytoprotective protein

 

Brenner, David

 

Individual Genetic Susceptibility

 

Brenner, David

 

Is Increased Low-Dose Somatic Radiosensitivity Associated with Increased Trans-Generational Germline Mutation Radiosensitivity?

 

Brenner, David

 

Virtual Colonoscopy: The Potential Benefits of Low-Dose Radiation Exposure Far Outweigh any Risks

 

Brooks, Antone

 

Optimizing the Scientific, Regulatory and Societal Impact of the DOE Low Dose Research Program

 

Chen, David

 

Mechanisms of the Adaptive Response to Radiation

 

Crawford-Brown, Douglas

 

Testing and Expansion of a Generalized StateVector Model for Radiation-Induced Cellular Transformation: in vitro Irradiation of Cells by Acute Doses of Xrays

 

Campisi, Judith

 

Radio-adaptive response accelerates resolution of IR-induced DNA damage foci and attenuates the senescence response in primary human fibroblasts

 

Chuang, Eric Y.

 

Abnormal Gene Expression Profiles in Unaffected Parents of Patients with Hereditary Retinoblastoma

 

Coleman, Matthew A

 

Molecular mechanisms and cellular consequences of low-dose exposure to ionizing radiation.

 

Coleman, Matthew A.

 

Using Co-Regulation to Understand Low-Dose Ionizing Radiation Responsive Genes and Pathways.

 

Conolly, Rory

 

Computational Modeling of Biochemical Pathways Linking Ionizing Radiation to Cell Cycle Arrest, Apoptosis, and Tumor Incidence

 

Cooper, Priscilla

 

Mechanisms of Low-Dose Inducible DNA Repair and the Adaptive Response

 

Cooper, Priscilla

 

Using LC-FTICR to Identify Protein Relocalization Patterns in Response to IR

 

Cornforth, Michael

 

mFISH Reveals an LET-Independent Excess of Radiation-Induced Dicentrics Involving Homologous Chromosomes

 

Du, Yu-Chun

 

The H2AX Complex Dynamics during DNA Repair Detected by a Dual-Tagging Proteomic Strategy Reveals the Critical Roles of Ca 2+/Calmodulin in the Ionizing-Radiation Induced Cell Cycle Arrest

 

Dupuis, Michael

 

Molecular Energetics of Clustered Damage Sites

 

Dynan, William

 

DNA Damage Response and Ku80 Function in the Vertebrate Embryo

 

Engleward, Bevin B.

 

‘Recombomice’ – A new tool for studying homologous recombination in vivo

 

Folkard, Melvyn

 

A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect.

 

Folkard, Melvyn

 

Targeted radiation studies in tissue explants

 

Fornace, A.J.

 

A functional genomics approach using radiation-induced chanes in gene expression to study low dose radiation effects in vitro and in vivo.

 

Geard, Charles R.

 

The Radiation-induced Bystander Response: Different Protocols, Similar Effects.

 

Goble, Robert

 

Tales from the Crypt: Hierarchical Modeling of Genomic Defense Mechanisms Related to Radiation-Induced Cancers


Goodwin, Edwin

 

Mechanisms of the Adaptive Response to Radiation

 

Grdina, David

 

Inhibition of NFκB DNA binding by helenalin abolishes the induced radioprotective effect by amifostine’s active metabolite WR1065 in human microvascular endothelial cells.

 

Green, Lora M.

 

Gene Expression in Thyroid Tissue Analogs Following Acute Low Dose and Low Dose Rate Gamma Irradiation

 

Green, Lora M. , Gridley, Daila

 

Mechanisms of Low Dose Radiation-induced T Helper Cell Function

 

Gridley, Daila

 

Long-Term Effects of Whole-Body, High-LET Radiation on Blood Chemistry

 

Griffith, William

 

Systems Biology Models as a Tool to Integrate Diverse Studies of the Developing Neocortex after Exposure to Low Dose Radiation

 

Griffith, William

 

Value of Information Approach for Constructing Models of Bystander Effects

 

Hall, Eric J.

 

Individual Genetic Susceptibility

 

Hazleton, William

 

Modeling Low-Dose Ionizing Radiation Effects: Influence of Cell Cycle Regulation on Tissue Homeostasis, Promotion, and Malignant Transformation.

 

Jirtle, Randy J.

 

Environmental Epigenomics and Adult Disease Susceptibility

 

Joiner, Michael C.

 

Lack of DNA-damage mediated ATM activation determines low-dose hyper-radiosensitivity.

 

Kadhim, Munira

 

Genomic instability induced by a bystander signal

 

Kohwi-Shigematsu, T.

 

The Effects of Ionizing Radiation on Chromatin Dynamics

 

Kronenberg, Amy

 

A quantitative assessment of bystander mutagenesis in the mouse mammary gland

 

Li, Chuan-Yuan

 

Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation

 

Li, Jian Jian

 

Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1

 

Marples, Brian

 

Lack of DNA-damage mediated ATM activation determines low-dose hyper-radiosensitivity.

 

Michael, Barry D.

 

A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect.

 

Michael, Barry D.

 

Targeted radiation studies in tissue explants

 

Miller, John H.

 

Radiation-induced protein release: A source of bystander signaling?

 

Miller, John H.

 

Comparison of Soft X Rays and Ions Irradiation in a Model of V79 Mammalian Cell

 

Moolgavkar, Suresh H.

 

Modeling Low-Dose Ionizing Radiation Effects: Influence of Cell Cycle Regulation on Tissue Homeostasis, Promotion, and Malignant Transformation.

 

Morgan, William F.

 

Genetic Factors Affecting Susceptibility to Low-Doses of Ionizing Radiation.

 

Morgan, William F.

 

Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation

 

Nagasawa, H.

 

Role of Homologous Recombination in the Alpha Particle Bystander Effect for Sister Chromatid Exchanges and Chromosomal Aberrations

 

Nagasawa, H.

 

Hypersensitivity of cultured fibroblasts from retinoblastoma family members and apparently normal controls: colony formation during continuous low-dose rate irradiation and G2 chromosomal radiosensitivity

 

Naterajan, Mohan

 

Real-time Study of Signal Transduction Pathways Involving in Bystander Effects Using Single Nanoparticle Optics and Single Living Cell Imaging

 

Naterajan, Mohan

 

Role of TNF-α as a potential Signaling Mediator of Radiation-induced Bystander Effect in Human Vascular Cells.

 

Nelson, David

 

Molecular mechanisms and cellular consequences of low-dose exposure to ionizing radiation.

 

Neta, Ruth

 

Russian Human Radiobiology Tissue Repository for the exposed Mayak PA workers

 

Opresko, Lee K.

 

Mechanism(s) of three-dimensional intercellular signaling in mammary epithelial cells in response to low dose, low-LET radiation: Implications for the radiation-induced bystander effect.

 

Pluth, Janice

 

Mechanisms of Low-Dose Inducible DNA Repair and the Adaptive Response

 

Prise, Kevin M.

 

Targeted radiation studies in tissue explants

 

Prise, Kevin M.

 

A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect.

 

Redpath, J. Leslie

 

Low dose studies of neoplastic transformation in vitro by low LET radiations

 

Rithidech, Kanokporn Noy

 

Induction of Genomic Instability in vivo by Low Doses of 137Cs γ rays.

 

Rodgers, Brenda

 

An Absolute Quantification Approach Using Real-Time PCR to Assess Transcript Number of Specific Proteins Involved in DNA Repair and Oxygen Radical Scavenging Mechanisms of Mus Musculus (BALB/c) Exposed to Low Dose Ionizing Radiation at Chernobyl.

 

Sachs, Rainer K.

 

Modeling Intercellular Interactions During Radiation Carcinogenesis

 

Sacksteder, Colette

 

Molecular Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation

 

Schild, David

 

Depletion of the vertebrate-specific Rad51-interacting protein Rad51AP1/Pir51 sensitizes human cells to MMC and X-rays

 

Schwartz, Jeffrey L.

 

Characteristics of Radiation-Induced Skin Cancers in Hematopoietic Stem Cell Transplantation Patients.

 

Scott, Bobby

 

NEOTRANS3 Model for Low-Dose-Induced Stochastic Radiobiological Effects

 

Sowa, Marianne B.

 

Mechanism(s) of three-dimensional intercellular signaling in mammary epithelial cells in response to low dose, low-LET radiation: Implications for the radiation-induced bystander effect.

 

Sowa, Marianne B.

 

Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation.

 

Spitz, Douglas R.

 

Chinese hamster fibroblasts containing mutations in succinate dehydrogenase subunit C (SDHC) demonstrate increased sensitivity to low dose ionizing radiation

 

Springer, David L.

 

Protein changes in media taken from irradiated CHO cells

 

Stewart, Robert D.

 

Implications of intercellular signaling for the shapes of dose-response relationships

 

Sutherland, Betsy M.

 

Endogenous and Radiation-induced DNA Damage Clusters: Insights on Induction and Repair in Human Skin, 3D Model Skin Systems and Hematopoietic Stem and Progenitor Cells*

 

Sykes, Pamela, J.

 

The pKZ1 inversion assay is a sensitive assay for lowdose Xradiation studies.

 

Thompson, Larry H.

 

Cooperation Between Homologous Recombination and the Fanconi Anemia Cancer Suppressor Proteins in Minimizing Spontaneous and Radiation-induced Chromosomal Instability

 

Toburen, Larry H.

 

Modeling Energy Deposition by Ionizing Radiation in a Cellular Environment

 

Vallis, Katherine A.

 

The Characterization of Genetic Responses to Low Dose Radiation using a Genome-Wide Insertional Mutagenesis Approach

 

Vo-Dinh, Tuan

 

Nanoprobes for Imaging Single Cells under Low-Dose Radiation

 

Voy, Brynn

 

Genetic Background Significantly Alters the Response to Low Dose Ionizing Radiation In Vivo

 

Wang, Daojing

 

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation

 

Warters, Raymond Leon

 

Ionizing radiation-induced DNA damage stress response in cultured human skin cells.

 

Weber, Thomas J.

 

A Paracrine Signal Mediates The Cell Transformation Response To Low Dose Gamma Radiation in JB6 Cells.

 

Wilson, Walter E.

 

Comparison of Soft X Rays and Ions Irradiation in a Model of V79 Mammalian Cell

 

Worgul, Basil

 

Individual Genetic Susceptibility

 

Worgul, Basil

 

Low LET Radiation Studies on the Protective Bystander Effect and Cataractogenesis

 

Wyrobek, Andrew J.

 

Molecular mechanisms and cellular consequences of low-dose exposure to ionizing radiation.

 

Yang, Feng

 

Phosphoproteome profiling of human skin fibroplast cells in response to low- and high-dose irradiation

 

Yannone, Steven, M.

 

Using LC-FTICR to Identify Protein Relocalization Patterns in Response to IR

 

Zimbrick, John D.

 

Transgenerational Effects of Chronic Low-Dose Irradiation in a Medaka Fish Model System.

 

 



                   
                   
                   
 

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