Low Dose Radiation Biology Research

Presented at: Low Dose Radiation Research Program Workshop November 1999

Author: AL Brooks

Date: 11/17/99

Table of Contents

• Low Dose Radiation Biology Research "Science in Support of Radiation Risk Policy"
• Current DOE Low-DoseProgram
• Interactions with otherPrograms
• How does Research Impact Standard Setting?
• Objectives
• Key Research AreasTechnological Developments
• Microbeam
• Impact on Standards
• Key Research AreasBiological Developments
• DNA Damage and Repair
• Impact of Genomics on Human Risk Assessment
• Impact on Standards
• Radiation induced Bystander Effects
• Changes in Gene Expression by ? particles:Cell/Cell Communication (Bystander Effect)
• Impact on Standards
• Adaptive Response for Radiation-induced Chromatid Aberrations
• Adaptive Responses for Leukemia
• Radiation Related GeneInduction(CDKN1A)
• Impact on Standards
• Radiation vs Endogenous Damage
• Statistical Barriers
• Biological Barriers (Lifespan)
• Energy Barriers
• Impact on Standards
• Frequency of ?-ray-induced Chromosomal Instability
• Genomic Instability as a Function of Mouse Strain (Black or White)
• Impact on Standards
• Genetic Susceptibility
• Impact on Standards
• Application of Information
• How will modelers use all these data?
• Chemical Models of Risk
• Radiation Models of Risk
• Research, Risk Assessment and Management
• The Key: Communication
• Goals of Communication
• Communication
• Communication
• How?
• Future Goals
• DOE Low-Dose Radiation Program
• EXTRA SLIDES
  • Adaptive Response
  • Radiation Related GeneInduction (CDKN1A)
  • PPT Slide
  • Genomic Instability
  • Cytogenetic aberrations in colonies derived from stem cells in marrow suspensions exposed to ?-particles or x-rays
  • Genetic Susceptibility