About the Low Dose Radiation Research Program

	Currently Funded Projects Linking to information: To find out more about the author, publications and abstracts click on his name. To find out more about the project click on the title. Links are usually a different color and underlined. The cursor becomes a hand icon pointing to linked text. Sally Amundson Center for Radiological Research, Columbia University sae2108@columbia.edu Mechanistic and Quantiative Studies of Bystander Response in 3-D Human Tissues for Low Dose Radiation Risk Estimation Carl W. Anderson Brookhaven National Laboratories cwa@bnl.gov Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Potential Application to p53 and Low Dose Ionizing Radiation Edouard Azzam UMDNJ- New Jersey Medical School aazzamei@umdnj.edu In vivo Mammalian Tissue Response to Low Dose Ionizing Radiation: The Role of Oxidative Metabolism and Intercellular Communication Radiation-Induced Modulation of Mitochondrial Protein Import Capacity in Normal Human Fibroblasts Cellular Responses to Low Dose/Very high Dose-Rate Ionizing Radiation: the Role of Endogenous Oxidative Metabolism Adayabalam Balajee Columbia University ab836@columbia.edu Cellular Response to Low Dose Radiation: Role of Phosphatidylinositol-3 Kinase Like Kinases Allan Balmain University of California, San Francisco, CA abalmain@cc.ucsf.edu Fbxw7/Cdc4 is a p53-dependent haploinsufficient tumour suppressor gene Identification of Mouse Genetic Susceptibility to Radiation Carcinogenesis An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue (This project is in collaboration with Mary Helen Barcellos-Hoff and jointly funded by NASA and DOE) Mary Helen Barcellos-Hoff New York University barcem01@nyumc.org Integrated Radiation Biology An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue (This project is in collaboration with Allan Balmain and jointly funded by NASA and DOE) Mechanisms of Tissue Response to Low Dose Radiation Multidimensional Analysis of Human Epithelial Cell Response to Low Dose Radiation Joel Bedford Colorado State University jbedford@colostate.edu Effects of SOD Down-Regulated Induced Adaptive Response and Bystander Effects Transgenerational Radiation Genetics: A feasibility Study for the Use of the Japanese Medaka to Investigate Adaptive Responses and Genomic Instability Genetic Factors Affecting Susceptibility to Low Dose and Low Dose-Rate Radiation Exposure Eleanor Blakely Lawrence Berkeley National Laboratory eablakely@lbl.gov Multi-cellular Crosstalk in Radiation Damage David A. Boothman University of Texas, Southwestern Medical Center, Dallas, TX david.boothman@utsouthwestern.edu The IGF-1/IGF-1R-MAPK-Secretroy Clusterin (sCLU) Pathway: Mediator of a Low Dose IR-inducible Bystander Effect Clusterin: A Low Dose IR-Inducible Molecular Switch Between Life and Death Simon Bouffler Health Protection Agency, Oxon, UK simon.bouffler@nrpb.org.uk Radiation Leukemogenesis at Low Dose Rates (NSCOR) (This NSCOR project is jointly funded by NASA and DOE) Return to the top Xian Chen Los Alamos National Laboratory xchen@telomere.lanl.gov Proteomic-Based Mechanistic Investigation of Low-Dose Radiation-Induced Cellular Responses/Effects Matthew Coleman Lawrence Livermore National Laboratory Coleman16@llnl.gov Using Co-Regulation to Understand Low-Dose Ionizing Radiation Responsive Genes and Pathways Priscilla Cooper Lawrence Berkeley Laboratory pkcooper@lbl.gov Role of p53 and DNA Repair in Radio-Adaptive Response and Low-Dose Hypersensitivity to Carcinogenic DNA Damage DNA Damage Responses to Low Dose Ionizing Radiation Mechanisms of Low-Dose Inducible DNA Repair and Adaptive Response Barbara Corbin Biomedical Research & Countermeasures Projects, NASA barbara.j.corbin@nasa.gov Lung Cancer, Pathogenesis and HZE Particle Exposure Michael Cornforth University of Texas Medical Branch mcornfor@utmb.edu Heritable Genetic Changes in Cells Recovered from Irradiated 3-D Tissue Constructs Cytogenetic Response to Low Doses of Ionizing Radiation (This project is jointly funded by NASA and DOE) Francis Cucinotta National Aeronaut & Space Administration francis.a.cucinotta@nasa.gov Radiation Sensitivity and Processingof DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair Deficient Cells (This project is jointly funded by NASA and DOE) Return to the top William Dynan Medical College of Georgia, Georgia Research Alliance wdynan@mail.mcg.edu Cellular and Molecular Studies of Radio-Adaptive Responses Low Dose Radiation Damage and Radioprotection in the Vertebrate Embryo Low Dose Radiation Damage and Radioprotection in the Vertebrate Embryo Bevin P. Engelward Division of Biological Engineering, MIT, Cambridge MA Bevin@MIT.edu 'Recombomice' - A New Tool for Studying Homologous Recombination In vivo Mechanisms of Low Dose Radio Suppression of Genomic Instability (This project is jointly funded by NASA and DOE) Charles Geard Columbia University crg4@columbia.edu The Adaptive Response, Genetic Haplo-insufficiency and Genomic Instability Defining a Possible Low LET Bystander Effect Lois Swirsky Gold University of California , Berkeley cpdb@potency.berkeley.edu Animal Cancer Tests and Human Cancer Risk Assessment: Margin of Exposure Risk Communication: A Broad Perspective on Human Cancer Risk at Low Doses of Chemicals Comparison of Risk Estimates Based on a Variety of Risk Assessment Methodologies Zelanna Goldberg Pharmacology & Toxicology, Graduate Program, University of California, Davis zelanna.goldberg@ucdmc.ucdavis.edu Genome-wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo, Low-Dose-LET Ionizing Radiation Exposure Evaluation of Genomic and Proteomic Responses to Low Dose IR Exposure in Patients Receiving Therapeutic Radiation Effects of Low Dose Ionizing Radiation on Gene Expression in Human Subjects Undergoing Radiotherapy David J. Grdina Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL. dgrdina@rover.uchicago.edu Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E Inhibition of NFkB DNA binding by helenalin abolishes the induced radioprotective effect by amifostine's active metabolite WR1065 in human microvascular endothelial cells Lora M. Green Radiobiology Program, Loma Linda University, Loma Linda CA 92354 lgreen@dominion.llumc.edu The Contribution of Tissue Level Organization to Genomic Instability Following Low Dose/Low Dose Rate Gamma and Proton Irradiation Low Dose Gamma Irradiation Potentiates Secondary Exposure to Gamma Rays or Protons in Thyroid Tissue Analogs (This project is jointly funded by NASA and DOE) Daila S. Gridley School of Medicine, Department of Microbiology and Molecular Genetics, Loma Linda University dgridley@dominion.llumc.edu T-helper Cell Gene Expression and Function in Response to Low Dose and Acute Radiation Mechanisms of Low Dose Radiation-Induced T Helper Cell Function (This project is jointly funded by NASA and DOE) Anthony James United States Transuranium and Uranium Registry, Washington State University tjames@tricity.wsu.edu Operation and Maintenance of the National Radiobiology Archives Randy L. Jirtle Duke University Medical Center, Durham, N.C jirtle@radonc.duke.edu Imprinted Genes and Transposons: Epigenomic Targets for Low Dose Radiation Effects (This project is jointly funded by NASA and DOE) Environmental Epigenomics and Adult Disease Susceptibility Munira Kadhim Radiation and Genome Stability Unit, Medical Research Council, Harwell, UK. m.kadhim@har.mrc.ac.uk Mechanisms Underlying Cellular Responses to Low Dose/Low LET Ionizing Radiation in Primary Haemopoeitic Cells Genomic Instability Induced by a Bystander Signal Norman Kleiman Environmental Health Sciences, Columbia University nik3@columbia.ed Low Dose Radiation Cataract Terumi Kohwi-Shigematsu Lawrence Berkeley National Laboratory TKohwi-Shigematsu@lbl.gov The Effect of Low-Dose Ionizing Radiation on Epigenetic Changes in Chromatin SATB1 Deficiency Accounts for High Susceptibility to Low Dose Radiation (This project is jointly funded by NASA and DOE) Return to the top John B. Little Department of Genetics and Complex Disease, Harvard School of Public Health jlittle@hsph.harvard.edu Bystander Effects in Ionizing Radiation Effect of lowdose alpha irradiation in human cells: the role of induced genes and the bystander effect Brian Marples Radiation Biology, William Beaumont Hospital Research Institute www.beaumonthospitals.com The Application of Flow Cytometry to Examine Damage Clearance in Stem Cells from Whole-body Irradiated Mice John Miller Washington State University Tri-Cities jhmiller@tricity.wsu.edu Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation Models for the Generation of Bystander Effects by Low Doses of Ionizing Radiation William Morgan Pacific Northwest National Laboratory wfmorgan@pnl.gov Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells. Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Genetic Factors Affect ing Susceptibility to Low-Dose Radiation Peter O'Neill Radiation and Genome Stability Unit, Medical Research Council p.oneill@har.mrc.ac.uk Radiation Sensitivity and Processing of DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair Deficient Cells (This project is jointly funded by NASA and DOE) Return to the top Janice Pluth Lawerence Berkeley National Laboratory, Life Sciences JMPluth@lbl.gov Radiation Sensitivity and Processing of DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair Deficient Cells (This project is jointly funded by NASA and DOE) J. Leslie Redpath University of California, Irvine jlredpat@uci.edu Molecular Mechanisms of Suppression of Neoplastic Transformation by Low Doses of Low LET Radiation Low Dose Suppression of Neoplastic Transformation In vitro (This project is jointly funded by NASA and DOE) Mechanisms Underlying the Adaptive Response against Spontaneous Neoplastic Transformation Induced by Low Doses of Low LET Radiation Collete Sacksteder Pacific Northwest National Laboratory Colette.Sacksteder@pnl.gov Molecular Mechanisms Underlying Cellular Adaptive Response to Low Dose Radiation Douglas R. Spitz Free Radical and Radiation Biology Program, Radiation Oncology, University of Iowa, Iowa City, USA douglas-spitz@uiowa.edu Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/LET Ionizing Radiation Chinese hamster fibroblasts containing mutations in succinate dehydrogenase subunit C (SDHC) demonstrate increased sensitivity to low dose ionizing radiation David Springer Pacific Northwest National Laboratory david.springer@pnl.gov Mitochondrial-derived Oxidants and Cellular Responses to Low-Dose/Low-LET Ionizing Radiation Regulated Proteolysis and Bystander Effects in Radiation David Stenoien Systems Biology, Pacific Northwest National Laboratory david.stenoien@pnl.gov Characterization of Signaling Events Induced by Low-Dose Ionizing Radiation Betsy Sutherland Brookhaven National Laboratory bms@bnl.gov Mechanisms of Human Skin Responses to Radiation Doses and Dose Rates DNA Damage Clusters in Low level Radiation Response of Human Cells (This project is jointly funded by NASA and DOE) Pamela Sykes Flinders University of South Australia pam.sykes@flinders.edu.au Mechanism for NonLinear Mutation Dose Response to Low-Dose and Ultra Low Doses of Low-LET Radiation The Role of Somatic Intrachromosomal Recombination in Response to Low-Dose x-Radiation Induced Genetic Damage Return to the top Larry H. Thompson Lawrence Livermore National Laboratory thompson14@llnl.gov Functional Assessment of Human Variation in Processing Clustered DNA Damage Assessing Biological Function of DNA Damage Response Genes (2) Robert Ullrich Colorado State University bullrich@colostate.edu Radiation Leukemogenesis at Low Dose Rates (NSCOR) (This NSCOR project is jointly funded by NASA and DOE) Genetic Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis Brynn Voy Oak Ridge National Laboratory voybh@ornl.gov Molecular Pathways that Mediate Genetic Susceptibility to Low Ionizing Radiation Genetic Background Significantly Alters the Response to Low Dose Ionizing Radiation In vivo Genetic Variation in Tissue Responses to Low-Dose Radiation Daojing Wang Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 djwang@lbl.gov Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation (This project is jointly funded by NASA and DOE) Ya Wang Thomas Jefferson University ya.wang@mail.tju.edu Characterization of the Role of Fhit in Maintenance of Genomic Integrity Following Low Dose Radiation In vivo and In vitro Raymond Leon Warters University of Utah Health Sciences Center ray.warters@hsc.utah.edu Characterization of the Role of TP53 Turnover Rates in Low IR Dose Sensitivity P ost-Translational Modifications of DNA Damage Response Proteins as a Measure of Cellular Response to Low Doses of Ionizing Radiation Thomas J. Weber Pacific Northwest National Laboratory thomas.weber@pnl.gov Cell Transforming Bystander Signals A Paracrine signal Mediates The cell Transformation Response to Low Dose Gamma Radiation in JB6 Cells Gayle Woloshack Northwestern University Medical School g-woloshack@northwestern.edu Radiation Risk from Chronic Low-Dose Rate Radiation Exposure: The Role of Life-Time Animal Studies- October Workshop Adaptive Response Mechanisms After Chronic Whole-body Exposure to Low-LET Radiation Radioprotectors and Tumors: Molecular Studies in Mice Andrew J. Wyrobek Lawrence Livermore National Laboratory wyrobek1@llnl.gov Molecular Mechanisms and Celluar Consequences of Low-Dose Exposure to Ionizing Radiation Molecular Mechanisms and Cellular Consequences of Low-Dose Exposures to DNA-Damaging Agents Chin-Rang Yang Simmons Comprehensive Cancer Center, University of Texas Southwest Branch chinrang.yang@southwestern.edu Non-Linear Systems Biology Approach to Model and Analyze the Dynamic Responses of Low-Dose Ionizing Radiation Zhi-min Yuan University of Texas yuanz@UTHSCSA Low Dose IR Creates an Oncogenic Microenviroment by Inducing Premature Senescence In Stromal Fibroblasts John D. Zimbrick Colorado State University john.zimbrick@colostate.edu Transgenerational Effects of Chronic Low-Dose Irradiation in a Medaka Fish Model System (This project is jointly funded by NASA and DOE) Return to the top

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