About the Low Dose Radiation Research Program

	Currently Funded Projects Linking to information: To find out more about the author, publications and abstracts click on his name. To find out more about the project click on the title. Links are usually a different color and underlined. The cursor becomes a hand icon pointing to linked text. Mechanistic and Quantiative Studies of Bystander Response in 3-D Human Tissues for Low Dose Radiation Risk Estimation Sally Amundson Center for Radiological Research, Columbia University sae2108@columbia.edu Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Potential Application to p53 and Low Dose Ionizing Radiation Carl W. Anderson Brookhaven National Laboratories cwa@bnl.gov In vivo Mammalian Tissue Response to Low Dose Ionizing Radiation: The Role of Oxidative Metabolism and Intercellular Communication Radiation-Induced Modulation of Mitochondrial Protein Import Capacity in Normal Human Fibroblasts Cellular Responses to Low Dose/Very high Dose-Rate Ionizing Radiation: the Role of Endogenous Oxidative Metabolism Edouard Azzam UMDNJ- New Jersey Medical School aazzamei@umdnj.edu Cellular Response to Low Dose Radiation: Role of Phosphatidylinositol-3 Kinase Like Kinases Adayabalam Balajee Columbia University ab836@columbia.edu Fbxw7/Cdc4 is a p53-dependent haploinsufficient tumour suppressor gene Identification of Mouse Genetic Susceptibility to Radiation Carcinogenesis An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue (This project is in collaboration with Mary Helen Barcellos-Hoff and jointly funded by NASA and DOE) Allan Balmain University of California, San Francisco, CA abalmain@cc.ucsf.edu Integrated Radiation Biology An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue (This project is in collaboration with Allan Balmain and jointly funded by NASA and DOE) Mechanisms of Tissue Response to Low Dose Radiation Multidimensional Analysis of Human Epithelial Cell Response to Low Dose Radiation Mary Helen Barcellos-Hoff Lawrence Berkeley National Laboratory mhbarcellos-hoff@lbl.gov Effects of SOD Down-Regulated Induced Adaptive Response and Bystander Effects Transgenerational Radiation Genetics: A feasibility Study for the Use of the Japanese Medaka to Investigate Adaptive Responses and Genomic Instability Genetic Factors Affecting Susceptibility to Low Dose and Low Dose-Rate Radiation Exposure Joel Bedford Colorado State University jbedford@colostate.edu Multi-cellular Crosstalk in Radiation Damage Eleanor Blakely Lawrence Berkeley National Laboratory eablakely@lbl.gov The IGF-1/IGF-1R-MAPK-Secretroy Clusterin (sCLU) Pathway: Mediator of a Low Dose IR-inducible Bystander Effect Clusterin: A Low Dose IR-Inducible Molecular Switch Between Life and Death David A Boothman University of Texas, Southwestern Medical Center, Dallas, TX david.boothman@utsouthwestern.edu Radiation Leukemogenesis at Low Dose Rates (NSCOR) (This NSCOR project is jointly funded by NASA and DOE) Simon Bouffler Health Protection Agency, Oxon, UK simon.bouffler@nrpb.org.uk Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program Antone Brooks Washington State University Tri-Cities tbrooks@tricity.wsu.edu Return to the top Proteomic-Based Mechanistic Investigation of Low-Dose Radiation-Induced Cellular Responses/Effects Xian Chen Los Alamos National Laboratory xchen@telomere.lanl.gov Using Co-Regulation to Understand Low-Dose Ionizing Radiation Responsive Genes and Pathways Matthew Coleman Lawrence Livermore National Laboratory Coleman16@llnl.gov Role of p53 and DNA Repair in Radio-Adaptive Response and Low-Dose Hypersensitivity to Carcinogenic DNA Damage DNA Damage Responses to Low Dose Ionizing Radiation Mechanisms of Low-Dose Inducible DNA Repair and Adaptive Response Priscilla Cooper Lawrence Berkeley Laboratory pkcooper@lbl.gov Lung Cancer, Pathogenesis and HZE Particle Exposure Barbara Corbin Biomedical Research & Countermeasures Projects, NASA barbara.j.corbin@nasa.gov Heritable Genetic Changes in Cells Recovered from Irradiated 3-D Tissue Constructs Cytogenetic Response to Low Doses of Ionizing Radiation (This project is jointly funded by NASA and DOE) Michael Cornforth University of Texas Medical Branch mcornfor@utmb.edu Radiation Sensitivity and Processingof DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair Deficient Cells (This project is jointly funded by NASA and DOE) Francis Cucinotta National Aeronaut & Space Administration francis.a.cucinotta@nasa.gov Return to the top Cellular and Molecular Studies of Radio-Adaptive Responses Low Dose Radiation Damage and Radioprotection in the Vertebrate Embryo Low Dose Radiation Damage and Radioprotection in the Vertebrate Embryo William Dynan Medical College of Georgia, Georgia Research Alliance wdynan@mail.mcg.edu 'Recombomice' - A new tool for studying homologous recombination in vivo Mechanisms of Low Dose Radio Suppression of Genomic Instability (This project is jointly funded by NASA and DOE) Bevin P. Engelward Division of Biological Engineering, MIT, Cambridge MA Bevin@MIT.edu The Adaptive Response, Genetic Haplo-insufficiency and Genomic Instability Defining a Possible Low LET Bystander Effect Charles Geard Columbia University crg4@columbia.edu Risk Communication: A Broad Perspective on Human Cancer Risk at Low Doses of Chemicals Comparison of Risk Estimates Based on a Variety of Risk AssessmentMethodologies Lois Swirsky Gold Children's Hospital and Research LSGold@lbl.gov Genome-wide Evaluation of Normal Human Tissue In Response to Controlled, in vivo, Low-Dose-LET Ionizing Radiation Exposure Evaluation of Genomic and Proteomic Responses to Low Dose IR Exposure in Patients Receiving Therapeutic Radiation Effects of Low Dose Ionizing Radiation on Gene Expression in Human Subjects Undergoing Radiotherapy Zelanna Goldberg Pharmacology & Toxicology, Graduate Program, University of California, Davis zelanna.goldberg@ucdmc.ucdavis.edu Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E. Inhibition of NFkB DNA binding by helenalin abolishes the induced radioprotective effect by amifostine's active metabolite WR1065 in human microvascular endothelial cells David J. Grdina Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL. dgrdina@rover.uchicago.edu The Contribution of Tissue Level Organization to Genomic Instability Following Low Dose/Low Dose Rate Gamma and Proton Irradiation Low Dose Gamma Irradiation Potentiates Secondary Exposure to Gama Rays or Protons in Thyroid Tissue Analogs (This project is jointly funded by NASA and DOE) Lora M. Green Radiobiology Program, Loma Linda University, Loma Linda CA 92354 lgreen@dominion.llumc.edu T-helper Cell Gene Expression and Function in Response to Low Dose and Acute Radiation Mechanisms of Low Dose Radiation-Induced T Helper Cell Function (This project is jointly funded by NASA and DOE) Daila S. Gridley School of Medicine, Department of Microbiology and Molecular Genetics, Loma Linda University dgridley@dominion.llumc.edu Individual Genetic Susceptibility (This project is jointly funded by NASA and DOE) Mechanisms of the Bystander Effects (This project is jointly funded by NASA and DOE) Eric Hall Center for Radiological Research, Columbia University ejh1@columbia.edu High-Resolution Infrared Spectromicroscopy for Molecular Characterization and Imaging of Bystander Effects in Real Time Hoi-Ying Holman Lawrence Berkeley National Laboratory hyholman@lbl.gov Operation and Maintenance of the National Radiobiology Archives Anthony James United States Transuranium and Uranium Registry, Washington State University tjames@tricity.wsu.edu Imprinted Genes and Transposons: Epigenomic Targets for Low Dose Radiation Effects (This project is jointly funded by NASA and DOE) Environmental Epigenomics and Adult Disease Susceptibility Randy L. Jirtle Duke University Medical Center, Durham, N.C jirtle@radonc.duke.edu Mechanisms Underlying Cellular Responses to Low Dose/Low LET Ionizing Radiation in Primary Haemopoeitic Cells Genomic Instability Induced by a Bystander Signal Munira Kadhim Radiation and Genome Stability Unit, Medical Research Council, Harwell, UK. m.kadhim@har.mrc.ac.uk Low Dose Radiation Cataract Norman Kleiman Environmental Health Sciences, Columbia University nik3@columbia.edu The Effect of Low-Dose Ionizing Radiation on Epigenetic Changes in Chromatin SATB1 Deficiency Accounts for High Susceptibility to Low Dose Radiation (This project is jointly funded by NASA and DOE) Terumi Kohwi-Shigematsu Lawrence Berkeley National Laboratory TKohwi-Shigematsu@lbl.gov Return to the top Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing Chaun-Yuan Li Radiation Biology Research, Duke University Medical Center cyli@radonc.duke.edu Radiobiology of Neural Cancer Stem Cells Charles Limoli Radiation Biology, University of California, Irvine climoli@uci.edu Bystander Effects in Ionizing Radiation Effect of lowdose alpha irradiation in human cells: the role of induced genes and the bystander effect John B. Little Department of Genetics and Complex Disease, Harvard School of Public Health jlittle@hsph.harvard.edu The Application of Flow Cytometry to Examine Damage Clearance in Stem Cells from Whole-body Irradiated Mice Brian Marples Radiation Biology, William Beaumont Hospital Research Institute www.beaumonthospitals.com Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation Models for the Generation of Bystander Effects by Low Doses of Ionizing Radiation John Miller Washington State University Tri-Cities jhmiller@tricity.wsu.edu Identification and Characterization of Soluble Factors Involved in Delayed Effects of Low Dose Radiation A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells. Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Genetic Factors Affect ing Susceptibility to Low-Dose Radiation William Morgan University of Maryland WFMorgan@som.umaryland.edu Radiation Sensitivity and Processing of DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair Deficient Cells (This project is jointly funded by NASA and DOE) Peter O'Neill Radiation and Genome Stability Unit, Medical Research Council p.oneill@har.mrc.ac.uk Return to the top Radiation Sensitivity and Processing of DNA Damage Following Low Doses of Gamma-ray, Alpha Particles, & HZE Irradiation of Normal or DSB Repair Deficient Cells (This project is jointly funded by NASA and DOE) Janice Pluth Lawerence Berkeley National Laboratory, Life Sciences JMPluth@lbl.gov Molecular Mechanisms of Suppression of Neoplastic Transformation by Low Doses of Low LET Radiation Low Dose Suppression of Neoplastic Transformation In Vitro (This project is jointly funded by NASA and DOE) Mechanisms Underlying the Adaptive Response against Spontaneous Neoplastic Transformation Induced by Low Doses of Low LET Radiation J. Leslie Redpath University of California, Irvine jlredpat@uci.edu Cytogenetic tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks Modeling the Interrelations Among Radiation-Induced Bystander Effects, Genomic Instability, and Cancer Rainer Sachs University of California, Berkeley, CA 74720 sachs@math.berkeley.edu Molecular Mechanisms Underlying Cellular Adaptive Response to Low Dose Radiation Collete Sacksteder Pacific Northwest National Laboratory Colette.Sacksteder@pnl.gov A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells Marianne B. Sowa PNNL - Pacific Northwest National Laboratory marianne.sowa@pnl.gov Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/LET Ionizing Radiation Chinese hamster fibroblasts containing mutations in succinate dehydrogenase subunit C (SDHC) demonstrate increased sensitivity to low dose ionizing radiation. Douglas R. Spitz Free Radical and Radiation Biology Program, Radiation Oncology, University of Iowa, Iowa City, USA douglas-spitz@uiowa.edu Mitochondrial-derived Oxidants and Cellular Responses to Low-Dose/Low-LET Ionizing Radiation Regulated Proteolysis and Bystander Effects in Radiation David Springer Pacific Northwest National Laboratory david.springer@pnl.gov Characterization of Signaling Events Induced by Low-Dose Ionizing Radiation David Stenoien Systems Biology, Pacific Northwest National Laboratory david.stenoien@pnl.gov Mechanisms of Human Skin Responses to Radiation Doses and Dose Rates DNA Damage Clusters in Low level Radiation Response of Human Cells (This project is jointly funded by NASA and DOE) Betsy Sutherland Brookhaven National Laboratory bms@bnl.gov Mechanism for NonLinear Mutation Dose Response to Low-Dose and Ultra Low Doses of Low-LET Radiation The Role of Somatic Intrachromosomal Recombination in Response to Low-Dose x-Radiation Induced Genetic Damage Pamela Sykes Flinders University of South Australia pam.sykes@flinders.edu.au Return to the top Functional Assessment of Human Variation in Processing Clustered DNA Damage Assessing Biological Function of DNA Damage Response Genes (2) Larry H. Thompson Lawrence Livermore National Laboratory thompson14@llnl.gov Radiation Leukemogenesis at Low Dose Rates (NSCOR) (This NSCOR project is jointly funded by NASA and DOE) Genetic Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis Robert Ullrich Colorado State University bullrich@colostate.edu Nanoprobes for Imaging Single Cells under Low-Dose Radiation. Tuan Vo-Dinh Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6101 vodinht@ornl.gov Molecular Pathways that Mediate Genetic Susceptibility to Low Ionizing Radiation Genetic Background Significantly Alters the Response to Low Dose Ionizing Radiation In Vivo Genetic Variation in Tissue Responses to Low-Dose Radiation Brynn Voy Oak Ridge National Laboratory voybh@ornl.gov Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation (This project is jointly funded by NASA and DOE) Daojing Wang Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 djwang@lbl.gov Characterization of the Role of Fhit in Maintenance of Genomic Integrity Following Low Dose Radiation in vivo and in vitro Ya Wang Thomas Jefferson University ya.wang@mail.tju.edu Characterization of the Role of TP53 Turnover Rates in Low IR Dose Sensitivity P ost-Translational Modifications of DNA Damage Response Proteins as a Measure of Cellular Response to Low Doses of Ionizing Radiation Raymond Leon Warters University of Utah Health Sciences Center ray.warters@hsc.utah.edu Cell Transforming Bystander Signals A Paracrine signal Mediates The cell Transformation Response to Low Dose Gamma Radiation in JB6 Cells Thomas J. Weber Pacific Northwest National Laboratory thomas.weber@pnl.gov Radiation Risk from Chronic Low-Dose Rate Radiation Exposure: The Role of Life-Time Animal Studies- October Workshop Adaptive Response Mechanisms After Chronic Whole-body Exposure to Low-LET Radiation Radioprotectors and Tumors: Molecular Studies in Mice Gayle Woloshack Northwestern University Medical School g-woloshack@northwestern.edu Molecular Mechanisms and Celluar Consequences of Low-Dose Exposure to Ionizing Radiation Molecular Mechanisms and Cellular Consequences of Low-Dose Exposures to DNA-Damaging Agents Andrew J. Wyrobek wyrobek1@llnl.gov Lawrence Livermore National Laboratory Non-Linear Systems Biology Approach to Model and Analyze the Dynamic Responses of Low-Dose Ionizing Radiation Chin-Rang Yang Simmons Comprehensive Cancer Center, University of Texas Southwest Branch chinrang.yang@southwestern.edu Low Dose IR Creates an Oncogenic Microenviroment by Inducing Premature Senescence In Stromal Fibroblasts Zhi-min Yuan Harvard School of Public Health, Harvard University zyuan@hsph.harvard.edu Transgenerational Effects of Chronic Low-Dose Irradiation in a Medaka Fish Model System (This project is jointly funded by NASA and DOE) John D. Zimbrick Colorado State University john.zimbrick@colostate.edu Return to the top

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