About the Low Dose Radiation Research Program

	Past Funded Projects Effects of Low Doses of Radiation DNA Repair (This project is jointly funded by NASA and DOE) Eric Ackerman eackerman@pnl.gov Pacific Northwest National Laboratory Comparison of Low-Dose Radiation, Endogenous Oxidants, and Micronutrient Deficiencies through Analyses of DNA Damage and Cellular Responses Bruce N. Ames bnames@uclink4.berkeley.edu University of California, Berkeley Fbxw7/Cdc4 is a p53-dependent haploinsufficient tumour suppressor gene Identification of Mouse Genetic Susceptibility to Radiation Carcinogenesis An Expression Array Strategy to Identify Mouse Strain-Specific DNA Damage Response Pathways in Mammary Tissue (This project is in collaboration with Mary Helen Barcellos-Hoff and jointly funded by NASA and DOE) Allan Balmain University of California, San Francisco, CA abalmain@cc.ucsf.edu Impact of Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation Janet Baulch jebaulch@ucdavis.edu University of California, Davis Interaction of Genome and Cellular Microenvironment Mina Bissell Lawrence Berkeley National Laboratory MJBissell@lbl.gov The Dynamic Behavior of Broken Chromosomes in Yeast Kerry Bloom DNA Damage vs. Cell Killing by Low-Dose Rate Gamma Radiation Ultra Sensitive Measures and Implications for Mechanistically Modeled Cancer Risk Kenneth T. Bogen bogen@LLNL.gov Lawrence Livermore National Laboratory The Adaptive Response in p53 Cancer-prone Mice: Loss of Heterozygosity and Chromosome Instability Douglas Boreham boreham@mcmaster.ca McMaster University The Role of the Number and Spacing of Electron Tracks on the Consequences of Low Dose Irradiation Leslie A. Braby abraby@tamu.edu Texas A&M University Is Increased Low-Dose Radiosenstivity Associated with Increased Transgenerational Germline Mutuation Radiosensitivity? Significance of the Bystander Effect: Modeling, Experiments, and More Modeling The Risk of Cancer Induction Due to Routine Mammographic Screening MFISH Measurements of Chromosomal Aberrations in Individual Exposed in Utero to Gamma-Ray Doses from 5 to 20 cGy David Brenner Center for Radiological Research, Columbia University djb3@columbia.edu Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program Tony Brooks Washington State University Tri-Cities tbrooks@tricity.wsu.edu Cellular and Molecular Studies of Radio-Adaptive Responses Judith Campisi Lawrence Berkeley National Laboratory JCampisi@lbl.gov Mechanistic Modeling of Bystander Effects: An Integrated Theoretical and Experimental Approach Biological Effects of Low-Dose and Low-Dose Rate Radiation Exposures: An Integrated Theoretical and Experimental Approach Aloke Chatterjee A_Chatterjee@lbl.gov Lawrence Berkeley National Laboratory Low Dose Radiation Induced Proteomic Responses in Mammalian Cells Genome-Wide Expression of LLIR and the Biological Consequences David Chen DHChen@lbl.gov Lawrence Berkeley National Laboratory Genome-Scale Modeling of Low Dose Irradiation Responses Using Micro Array Based Gene Networks Matthew Coleman coleman16@llnl.gov Lawrence Livermore National Laboratory Use of Computational Modeling to Evaluate Hypotheses About the Molecular and Cellular Mechanisms of Bystander Effects Rory Conolly Website: http://209.183.221.234/AI/AF/winners.asp Rconolly@ciit.org Chemical Institute for Industrial Toxicology Research Triangle Park, NC 27709 Use of a State-Vector Model of Radiation Carcinogenesis to Integrate Information from In vitro, In vivo, Epidemiological and Physiological Studies Douglas Crawford-Brown University of North Carolina, Chapel Hill, NC 27599 douglas_crawford-brown@unc.edu Molecular Energetics of Clustered Damage Sites Michael Dupuis michel.dupuis@pnl.gov Pacific Northwest National Laboratory Genomic Instability Induced by Low Dose Radiation Helen Evans hhe2@po.cwru.edu Case Western Reserve University Understanding the Issues in Communicating about Low Dose Radiation Exposure James Flynn A Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced BystanderEffect Melvyn Folkard folkard@graylab.ac.uk Gray Cancer Institute Low Dose Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue Constructs (This project is jointly funded by NASA and DOE) John R. Ford Texas A & M University ford@ne.tamu.edu A Functional Genomics Approach Using Radiation-Induced Changes in Gene Expression to Study Low Dose Radiation Effects In Vitro and In Vivo Albert J. Fornace Jr. National Cancer Institute, National Institutes of Health fornace@nih.gov Monitoring Radiation-Induced Single Strand Breaks in DNA and their Repair John Game JCGame@lbl.gov Lawrence Berkeley National Laboratory Tales from the Crypt: Hierarchical Modeling of Genomic Defense Mechanisms Related to Radiation-Induced Cancers Robert Goble Clark University, Worcester, MA 01610 rgoble@clarku.edu Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment Edwin H. Goodwin Los Alamos National Laboratory goodwin_edwin_h@lanl.gov Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment Biological Effects of Low level Ionizing Radiation and Normal Oxidative Damage: The Same or Different? Edwin H. Goodwin egoodwin@telomere.lanl.gov Los Alamos National Laboratory Multi-level Kinetic and Dynamic Biologically Based Risk Models for Low Dose Radiation William Griffith University of Washington, Seattle, WA 98105 Griffith@u.washington.edu Genetic Control of Repair and Adaptive Responses to Low-level DNA Damage James Haber haber@hydra.rose.brandeis.edu Brandeis University Individual Genetic Susceptibility (This project is jointly funded by NASA and DOE) Mechanisms of the Bystander Effects (This project is jointly funded by NASA and DOE) Eric Hall Center for Radiological Research, Columbia University ejh1@columbia.edu Biologically-Based Multistage Modeling of Radiation Effects William Hazelton hazelton@fhcrc.org Fred Hutchinson Cancer Institute, Seattle, WA 98105 Models of Radiation Induced Translocations Applied to Human Leukemia Risk Estimation David G. Hoel High-Resolution Infrared Spectromicroscopy for Molecular Characterization and Imaging of Bystander Effects in Real Time Hoi-Ying Holman Lawrence Berkeley National Laboratory hyholman@lbl.gov Lack of DNA-Damage Mediated ATM Activiation Determines Low-Dose Hyper-Radiosensitivity Department of Radiation Oncology, Wayne State University Mechanisms of Enhanced Cell Killing at Low Doses: Application for Radiation Risk Michael C. Joiner Wayne State University Mechanisms of Enhanced Cell Killing at Low Doses: Application for Radiation Risk Peter J. Johnston johnston@gci.ac.uk Gray Cancer Institute A Novel Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation Gregory A. Kimmel gregory.kimmel@pnl.gov Pacific Northwest National Laboratory A Quantitative Assessment of Bystander Mutagenesis in the Mouse Mammary Gland In Vivo Amy Kronenberg a_kronenberg@lbl.gov Life Sciences Division, Lawrence Berkeley National Laboratory Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment Bruce E. Lehnert Los Alamos National Laboratory Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing Chaun-Yuan Li Radiation Biology Research, Duke University Medical Center cyli@radonc.duke.edu Regulation of NF-kB and Mn SOD in Low Dose Radiatoin Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li School of Health Sciences, Purdue University jjli@Purdue.edu Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells Howard Liber hliber@colostate.edu Colorado State University Radiobiology of Neural Cancer Stem Cells Charles Limoli Radiation Biology, University of California, Irvine climoli@uci.edu Low-Dose Studies with Focused X-rays in Cell and Tissue Models: Mechanisms of Bystander and Genomic Instability Responses Barry Michael micael@graylab.ac.uk Gray Laboratory Cancer Research Trust Mount Vernon Hospital Human Lung Cancer Progression Model for HZE Particle Exposure (This NSCOR project is jointly funded by NASA and DOE) John Minna john.minna@utsouthwestern.edu University of Texas, Southwestern Medical Center DNA Repair Gene Variants: Understanding Mechanisms of Cellular Response and Estimating Individual Health Risk from Low-Dose Radiation Exposure Harvey Mohrenweiser Stochastic Models for Low LET Radiation Risk Estimation at Low Dose and Dose Rate Suresh H. Moolgavkar smpp.gav@fhcrc.org University of Washington Development of PCR Based Methods for the Detection of Mutagenic Effects of Ionizing Radiation Alec Moreley Sensitivity to Radiation-Induced Cancer in Hemachromatosis. James E. Morris Real-Time Molecular Study of Bystander Effect Using Living Cell Imaging and Nanaparticles Optics Molecular Characterization of Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Real-time Study of Signal Transduction Pathways Involving in Bystander Effects Using Single Nanoparticle Optics and Single Living Cell Imaging Mohan Natarajan natarajan@uthscsa.edu University of Texas Health Science Center Methods for Deriving Gene and Pathway Specific Dose Response Curves from Expression Experiments Using DNA Microarrays David Nelson Lawerence Livermore National Laboratory Mechanisms(s) of Three-Dimensional Intercellular Signaling in Mammary Epithelial Cells in Response to Low Dose, Low-LET Radiation: Implications for the Radiation-Induced Bystander Effects Lee Opresko lee.opresko@pnl.gov Pacific Northwest National Laboratory A Novel, Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation Thom Orlando Repair of DNA Damage Induced by Ionizing Radiation and Other Oxidative Agents in Yeast and Human Louise Prakash loprakas@utmb.edu University of Texas Bystander and Adaptive Responses in Tissue Models Exposed to Low Radiation Doses Kevin Prise prise@gci.ac.uk Gray Cancer Institute Genetic Variation in Tissue Responses to Low-Dose Radiation Eugene Rinchik rinchikem@ornl.gov Oak Ridge National Laboratory Induction of Genomic Instability In Vivo by Low Doses of 137Cs Gamma Rays Kanokporn Rithidech krithid@notes.cc.sunysb.edu University of New York at Stony Brook Transcriptional and Radio-Adaptive Responses to Low Dose Rate Environmental Exposures to The Radioactive Fallout at Chornobyl Brenda Rodgers brodgers@mail.wtamu.edu West Texas A&M University Cytogenetic tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks Modeling the Interrelations Among Radiation-Induced Bystander Effects, Genomic Instability, and Cancer Rainer Sachs University of California, Berkeley, CA 74720 sachs@math.berkeley.edu Linking Molecular Events to Cellular Responses at Low Dose Exposures Jeffrey Saffer Quantification of Repair of Low-Dose-Induced DNA Double-Strand Breaks in Diploid Human Cells David Schild DSchild@lbl.gov Lawrence Berkeley National Laboratory Radiation Sensitivity and Cancer Susceptibility Jeffrey Schwartz jschwart@u.washington.edu University of Washington Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low-Dose, Low-Dose-Rate Exposures Biological-Based Modeling of Low Dose Radiation Risks Bobby Scott Lovelace Biomedical & Environmental Research Institute BScott@Lrri.org Direct Characterization of the Differences Between DNA Damage for Ionizing Radiation and Endogenous Oxidative Processes Richard D. Smith rd_smith@pnl.gov Pacific Northwest National Laboratory A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells Marianne B. Sowa PNNL - Pacific Northwest National Laboratory marianne.sowa@pnl.gov Towards Constructing and Testing a Virtual Tissue Kinetic Modeling of Damage Repair, Genome Instability, and Neoplastic Transformation Robert D. Stewart trebor@purdue.edu Purdue University, West Lafayette, IN 47907-2051 Nanoprobes for Imaging Single Cells under Low-Dose Radiation. Tuan Vo-Dinh Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6101 vodinht@ornl.gov Assessing Biological Function of DNA Damage Response Genes (1) Larry H. Thompson thompson14@llnl.gov Lawrence Livermore National Laboratory Biology and Biotechnology Research Program Modeling the Physics of Damage Cluster Formation in a Cellular Environment Larry H. Toburen toburenl@mail.ecu.edu East Carolina University Role of the Adaptive Response in Determining Health Risks from In Vivo Exposures to Low Dose of Ionizing Radiation Jim Tucker The Characterization of Genetic Responses to Low Dose Radiation Using a Genome-Wide Insertional Mutagensis Approach Katherine Vallis katherine.vallis@rmp.uhn.on.ca Princess Margaret Hospital Free Radical DNA Damage Produced Endogenously and by Low Dose Radiation in Human Cells: Quantitation, Consequences, and Repair Susan S. Wallace swallace@zoo.uvm.edu University of Vermont Communicating and Assessing the Science of the Low Dose Radiation Research Program John S. Wassom jsw@ornl.gov Oak Ridge National Laboratory Linking Molecular Events to Cellular Responses at Low Dose Exposures Thomas Weber Thomas.Weber@exchange.pnl.gov Pacific Northwest National Laboratory Murine Models of Radiation Sensitivity Michael Weil sa64001@odin.mdacc.tmc.edu University of Texas, MD Anderson Cancer Center Monte Carlo Track Structure Simulations for Low-LET Selected Cell Radiation Studies Walter E. Wilson wwilson@tricity.wsu.edu Washington State University Tri-Cities Low-LET Radiation Studies on the Protective Bystander Effect in an Organized Tissue Basil Worgul bvw1@columbia.edu Columbia University Return to the top

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