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Identification
of Mouse Genetic Susceptibility to Radiation Carcinogenesis
Allan Balmain
Why
this Project?
To identify
pathways that control genetic susceptibility to radiation-induced
DNA damage and tumor development using novel developments in
genomics together with mouse genetics.
Project
Goals:
- To
identify genetic loci that trigger rapid tumor development
of mice after radiation.
- To
characterize new genes at these loci that act as tumor suppressor
genes or oncogenes.
Experimental
Approach:
New candidate-radiation
susceptibility genes will be identified using a unique haplotyping
approach. Using DNA from radiation-induced lymphoma, changes
in the gene copy number can be detected using BAC microarrays.
The copy number and the genes involved in radiation-response
in both normal tissues and tumors will be identified. This approach
can help characterize the genetic basis for radiation sensitivity.
Expected
Outcomes:
Such research
will help clarify the genetic basis for increased or decreased
radiation susceptibility in humans and help define the radiation
risk in such populations.
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