Barcellos-Hoff, M.H. (2008) Cancer
is an emergent phenomenon in systems radiation biology.
Radiation Environ. Biophys. 47(1):33-38.
Raman, S., Maxwell, C.A., Barcellos-Hoff,
M.H., and Parvin, B. (2007) Geometric approach to segmentation
and protein localization in cell culture assays. Journal
of Microscopy-Oxford 225(1):22-30.
Costes, S.V., Ponomarev, A., Chen, J.L.,
Nguyen, D., Cucinotta, F.A., and Barcellos-Hoff,
M.H. (2007) Image-based modeling reveals dynamic
redistribution of DNA damage into nuclear sub-domains. PLOS
Computational Biology 3(8):1477-1488.
Andarawewa, K.L., Paupert, J., Pal, A.,
and Barcellos-Hoff, M.N. (2007) New rationales for using
TGF-beta inhibitors in radiotherapy. International J. of
Radiation Biology 83(11-12):803-811.
Kumari, I., Andarawewa, K.L., Erickson,
A.C., Chou, W.S., Costes, S.V., Gascard, P., Mott, J.D.,
Bissell, M.J., and Barcellos-Hoff, M.H. (2007)
Ionizing radiation predisposes nonmalignant human mammary
epithelial cells to undergo transforming growth factor ß-induced
epithelial to mesenchymal transition. Cancer Research 67(18):8662-8670.
Parvin, B., Yang, Q., Han, J., Chang, H.,
Rydberg, B., and Barcellos-Hoff, M.H. (2007)
Iterative voting for inference of structural saliency and
characterization of subcellular events. IEEE Transactions
on Image Processing 16(3):615-623.
Barcellos-Hoff, M.H. and
Ortiz-de-Solorzano (2007) Quantitative in
vivo microscopy:
The return from the 'omics.' Current Opinion in Biotechnology 17:501-510.
Kirshner, J., Jobling, M.F., Pajares, M.J.,
Ravani, S.A., Glick, A.B., Lavin, M.J., Koslov, S., Shiloh,
Y., and Barcellos-Hoff, M.H. (2006) Inhibition
of transforming growth factor-ß1 signaling attenuates
ataxia talangiectasia mutated activity in response to genotoxic
stress. Cancer
Research 66(22):10861-10869.
Barcellos-Hoff, M.H. and
Costes, S.V. (2006) A systems biology approach to multicellular
and multi-generational radiation responses. Mutation
Research 597(1-2):32-38.
Costes, S.V., Boissière, A., Ravani, S., Romano, R., Parvin, B., and Barcellos-Hoff, M.H. (2006) Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts. Radiation Research 165(5):505-515.
Jobling, M.F., Mott, J.D., Finnegan, M.T.,
Vladimir, J., Erickson, A.C., Walian, P.J., Taylor, S.E.,
Ledbetter, S., Lawrence, C.M., Rifkin, D.B., and Barcellos-Hoff,
M.H. (2006) Isoform-specific activation
of latent transforming growth factor β (LTGF-β)
by reactive oxygen species. Radiation Research 166:839-848.
Barcellos-Hoff, M.H. (2005)
Integrative radiation carcinogenesis: Interactions between
cell and tissue responses to DNA damage. Seminars in
Cancer Biology 15:138-148.
Barcellos-Hoff, M.H. (2005)
How tissues respond to damage at the cellular level: Orchestration
by transforming growth factor-β (TGF-β). Br.
J. Radiol. Supplement 27:123-127.
Barcellos-Hoff, M.H., Park, C., and Wright, E.G. (2005) Radiation and the microenvironment – tumorigenesis and therapy. Nature Reviews Cancer 5(11):867-75.
Stone, H.B., Moulder, J.E., Coleman, C.N.,
Ang, K.K., Anscher, M.S., Barcellos-Hoff, M.H., Dynan,
W.S., Fike, J.R., Grdina, D.J., Greenberger, J.S., Hauer-Jenson,
M., Hill, R.P., Kolesnick, R.N., Mac Vitties, T.J., Marks,
C., McBride, W.H., Metting, N., Pellmar, T., Purucker, M.,
Robbins, M.E., Schiestl, R.H., Seed, T.M., Tomaszewski, J.E.,
Travis, E.L., Wallner, P.E., Wolpert, M., and Zaharevitz,
D. (2004) Models for evaluating agents intended for the prophylaxis,
mitigation and treatment of radiation injuries: Report of
an NCI workshop, December 3-4, 2003. Radiation Research 162:711-728.
Muraoka-Cook, R.S., Kurokawa, H., Koh, Y.,
Forbes, J.T., Roebuck, L.R., Barcellos-Hoff, M.H., Moody,
S.E., Chodosh, L.A., and Arteaga, C.L. (2004) Conditional
overexpression of active transforming growth factor β1 in
vivo accelerates metastes of transgenic mammary tumors. Cancer
Research 64:9002-9011.
Coleman, C.N., Stone, H.B., Alexander, G.A., Barcellos-Hoff,
M.H., Bedford, J.S., Bristow,
R.G., Dynlacht, J.R., Fuks, Z., Gorelic, L.S., Hill, R.P., Joiner,
M.C., Liu, F.-F., McBride, W.H., Mckenna, W.G.,
Powell, S.N., Robbins, M.E.C., Rockwell, S., Schiff, P.B.,
Shaw, E.G., Siemann, D.W., Travis, E.L., Wallner, P.E.,
Wong, R.S.L., and Zeman, E.M. (2003) Education and training
for radiation scientists: Radiation Research Program and
American Society of Therapeutic Radiology and Oncology
Workshop, Bethesda, Maryland, May 12-14, 2003. Radiation
Research 160:729-737.
Barcellos-Hoff,
M.H. (2003) How radiation-induced phenotypes contribute to neoplastic progression. Health Physics 85(1):84.
Parvin,
B., Yang, Q., Fontenay, G., and Barcellos-Hoff,
M.H. (2002) Biosig: An imaging bioinformatic system
for studying protenomics. Piscataway, NJ : IEEE Press,
pp. 1-17.
Costes,
S. and Barcellos-Hoff,
M.H. (2002)
Radiation quality and tissue-specific micoenvironments
following exposure to 1 GeV/AMU Fe. Advances in Space
Research 30(4):865-870.
Park,
C.C., Henshall-Powell, R., Erickson, A.C., Talhouk, R.,
Parvin, B., Bissell, M.J., and Barcellos-Hoff,
M.H.
(2003) Ionizing radiation induces heritable disruption of
epithelial cell-microenvironment interactions. Proc.
Natl. Acad. Sci. 100:10728-10733.
Ewan,
K.B., Henshall-Powell, R.L., Ravani, S.A., Pajares, M.J.,
Arteaga, C., Warters, R., Akhurst, R.J., and Barcellos-Hoff,
M.H. (2002)
Transforming growth factor-{beta}1 mediates cellular response
to DNA damage in situ. Cancer Res. 62:5627-5631.
Barcellos-Hoff, M.H., (2002) The contribution of radiation-induced microenvironments to neoplastic progression. Radiation Research 158(6):792-793.
Asch,
B.B. and Barcellos-Hoff, M.H. (2001) Epigenetics
and breast cancer. J. Mammary Gland. Biol. Neoplasia 6(2):151-152.
Barcellos-Hoff,
M.H. and Brooks, A.L. (2001). Extracellular signalling
through the microenvironment: A hypothesis relating
carcinogenesis, bystander effects and genomic instability. Radiation
Research
156:618-627.
Barcellos-Hoff,
M.H. (2001) It takes a tissue to make a tumor: Epigenetics,
cancer and microenvironment. J. Mammary Gland. Biol. Neoplasia
6(2):213-221.
Barcellos-Hoff,
M.H. (2001) Three down and counting: The transformation
of human mammary cells from normal to malignant in three steps.
Trends Mol. Med. 7(4):142-143.
Barcellos-Hoff,
M.H. and Ravani, S.A. (2000) Irradiated mammary
gland stroma promotes the expression of tumorigenic potential
by unirradiated epithelial cells. Cancer Res. 60:1254-1260.
Park,
C.C., Bissell, M.J., and Barcellos-Hoff, M.H. (2000)
The influence of microenvironment on malignant phenotype. Molecular
Medicine Today 6:324-329.
Chang,
P.Y., Bjornstad, K.A., Chang, E., McNamara, M., Barcellos-Hoff,
M.H., Lin, S.P., Aragon, G., Polansky, J.R., Lui, G.M. and
Blakely, E.A. (2000) Particle irradiation induces FGF2 expression
in normal human lens cells. Radiation Research 154:477-484.
Ehrhart,
E.J., Carroll, A., Segarini, P., Tsang, M.L..S., and Barcellos-Hoff,
M.H. (1997) Latent transforming growth factor-ß
activation in situ: Quantitative and functional
evidence following low dose irradiation. FASEB J 11:991-1002.
