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Transgenerational
Radiation Genetics: A feasibility Study for the Use of the Japanese
Medaka to Investigate Adaptive Responses and Genomic Instability
Joel S. Bedford
jbedford@colostate.edu
Department of Environmental and
Radiological
Health Science
Colorado State University, Fort Collins, Colorado
Website: http://www.cvmbs.colostate.edu/radiology
Why
this Project?
To determine if it is possible for either radiation-induced
adaptive responses or genomic instability to be transmitted
from one generation to the next by mutational mechanisms.
Project
Goals:
- To provide
preliminary information needed to determine whether more extensive
studies in mammals are necessary to determine the importance
of trans-generational transmission of these radiation responsiveness
traits.
- To test
the assumption that adaptive responses and genomic instability
are not transmitted from one generation to the next.
Experimental
Approach:
This pilot
study can be rapidly conducted because fo the short generation
time of the fish Japanese Medaka and the large number of offspring
per generation. Male fish will be exposed to ionizing radiation
to determine if adaptive responses or genomic instability can
be transmitted at a high frequency from one generation to the
next.
Expected
Outcomes:
- Determination
of heritability of radiation–induced adaptive responses
or genomic instability in the Japanese Medaka.
- These
results will show that radiation risk in radiated offspring
may be increased or decreased and therefore should be considered
in future risk assessments.
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