About the Program :)
















 

Albert J. Fornace, Jr.
National Cancer Institute, U.S. National Institutes of Health
E-mail: fornace@nih.gov
Website: http://rex.nci.nih.gov/RESEARCH/basic/lbc/ajfornace.htm


Currently Funded Projects:
Technical Abstracts:

Low Dose-Rate Radiation Effects on Gene Expression.
Amundson, S.A., Lee, R.A., and Fornace, A.J., Jr.

  • 2001 Workshop:
  • 1999 Workshop:
Publications:

Amundson, S.A., Do, K.T., Vinikoor, L.C., Lee, R.A., Koch-Paiz, C.A., Ahn, J., Reimers, M., Chen, Y., Scudiero, D.A., Weinstein, J.N., Trent, J.M., Bittner, M.L., Meltzer, P.S., and Fornace, A.J. , Jr. (2008) Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute anticancer drug screen. Cancer Research 68(2):415-424.

Dudgeon, C., Kek, C., Demidov, O.N., Saito, S., Fernandes, K., Diot, A., Bourdon, J-C., Lane, D.P., Appella, E., Fornace, A.J., Jr., and Bulavin, D.V . (2006) Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene. Cancer Research 66(6):2928-2936.

Shreeram, S., Demidov, O.N., Hee, W.K., Yamaguchi, H., Onishi, N., Kek, C., Timofeev, O.N., Dungeon, C., Fornace, A.J., Jr., Anderson, C.W., Minami, Y., Appella, E., and Bulavin, D.V. (2006) Wip1 phosphatase modulates ATM-dependent signaling pathways. Molecular Cell.23: 757-764.

Sheeram, S., Hee, W.-K., Demidov, O.N., Kek, C., Yamaguchi, H., Fornace, A.J., Jr., Anderson, C.W., Appella, E., and Bulavin, D.V. (2006) Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip 1 phosphatase. Journal of Experimental Medicine. 203:2793-2799.

Amundson, S. A, Do, K.T. Vinikoor, L., Koch-Paiz, C.A., Bittner, M.L., Trent, J.M., Meltzer, P.,  and Fornace, A.J., Jr.  (2005) Stress-specific signatures:  Expression profiling of p53 wild-type and null human cells.  Oncogene 24:4572-4579.

Denko, N.C. and Fornace, A.J., Jr. (2005) Editorial comment: Mutation Research Special issue on stress response. Mutation Research 569:1-2.

Amundson, S.A., Grace, M.B., McLeland, C.B., Epperly, M.W., Yeager, A., Zhan, Q., Greenberger, J.S., and Fornace, A.J., Jr. (2004) Human in vivo radiation-induced biomarkers: Gene expression changes in radiotherapy patients. Cancer Research 64:6368-6371.

Amundson, S.A., Bittner, M., and Fornace, A.J., Jr. (2003) Functional genomics as a window on radiation stress signaling. Oncogene 22(37):5828-5833.

Admundson, S.A. and Fornace, A.J., Jr. (2003) Monitoring human radiation exposure by gene expression profiling: Possibilities and pitfalls. Health Physics 85(1):36-42.

Amundson, S.A., Lee, A., Koch-Paiz, C.A., Bittner, M.L., Meltzer, P., Trent, J.M., and Fornace, A.J., Jr. (2003) Differential responses of stress genes to low dose-rate γ irradiation.  Molecular Cancer Res. 1:445-452.

Amundson,, S.A., Patterson, A., Do, K.T., and Fornace, A.J., Jr. (2002)  A nucleotide excision repair master-switch:  p53 regulated coordinate induction of global genomic repair genes. Cancer Biology and Therapy 1:145-149.

Amundson, S.A., Bittner, M., and Fornace A.J., Jr. (2002) Genome-wide transcriptional response at low doses: The power of microarray technology. Radiation Research 158(6):791-792.

Amundson, S.A., Do, K.T., Meltzer P., Trent, J., Bittner, M., and Fornace, A.J., Jr. (2002) Stress gene induction by low-dose gamma-irradiation. Military Medicine 167(2):13-15.

Amundson, S.A., Meltzer, P., Trent, J., Bittner, M., and Fornace, A.J., Jr. (2001) Induction of gene expression as a monitor of ionizing radiation exposure. Radiation Research 156:657-661.

Amundson, S.A. and Fornace, A.J., Jr. (2001) Gene expression profiles for monitoring radiation exposure. Radiation Protection Dosimetry 97(1):11-16.

Amundson, S.A., Bittner, M., Meltzer, P., Trent, J., and Fornace, A.J., Jr. (2001) Physiological function as regulation of large transcriptional programs: The cellular response to genotoxic stress. Comp. Biochem. Physiol. (B) 129:703-710.

Amundson, S.A., Bittner, M., Meltzer, P., Trent, J., and Fornace, A. J., Jr. (2001) Biological indicators for the identification of radiation exposure in humans. Expert Rev. Mol. Diagn. 1(2):211-219.

Amundson, S.A., Do, K.T., Shahab, S., Bittner, M., Meltzer, P., Trent, J., and Fornace, A.J., Jr. (2000) Identification of potential mRNA biomarkers of human ionizing radiation exposure in peripheral blood lymphocytes. Radiation Research 154(3):342-346.

Bittner, M., Chen, Y., Amundson, S.A., Khan, J., Fornace, A.J., Jr., Dougherty, E., Meltzer, P.S., and Trent, J.M. (2000) Obtaining and evaluating gene expression profiles with cDNA microarrays. In: Genomics and proteomics, Suhai, S. (Ed.). New York : Kluwer Academic/Plenum Publishers, pp. 5-25.

Koch-Paiz, C.A., Momenan, R., Amundson, S.A., Lamoreaux, E., and Fornace, A.J., Jr. (2000) Estimation of relative mRNA content by filter hybridization to a polyuridylic probe. Biotechniques 29(4):706-714.

Amundson, S.A., Bittner, M., Chen, Y., Trent, J., Meltzer, P., and Fornace, A.J., Jr. (1999) Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18:3666-3672.

Amundson, S.A., Do, K.T., and Fornace, A.J., Jr. (1999) Stress gene induction by low doses of gamma-rays. Radiation Research 152(3):225-231.

Fornace, A.J., Jr., Amundson, S.A., Bittner, M., Myers, T.G., Meltzer, P., Weinstein, J.N., and Trent, J. (1999) Complexity of radiation stress responses: Analysis by informatics and functional genomics approaches. Gene Expression 7:387-400.

Sheikh, M.S. and Fornace, A.J., Jr. (1999) Regulation of translation initiation following stress. Oncogene 18(45):6121-6128.

Zhan, Q., Bae, I., Kastan, M.B., and Fornace, A.J., Jr. (1994) The p53-dependent gamma-ray response of GADD45. Cancer Research 54(10):2755-2760.

 
 



                   
                   
                   
 

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