David J. Grdina
Department of Radiation and Cellular Oncology,
The University of Chicago, Chicago, IL.
E-mail: dgrdina@rover.uchicago.edu
Website:http://www.radonc.uchicago.edu/typea/fac_dgrdina.html

---

Currently Funded Projects:

Prevention of Low Dose Radiation-Induced Genomic Instability with Cllinically Relevant Non-Protein Thiols and Vitamin E.

About This Project:

Inhibition of NFκB DNA Binding by Helenalin Abolishes the Induced Radioprotective Effect by Amifostine’s Active Metabolite WR1065 in Human Microvascular Endothelial Cells. Abstract. Description.

Technical Abstracts:

• 2006 Workshop:
  Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E.
  Murley, J.S., Kataoka, Y., Morgan, W.F., and Grdina, D.J.
  
  Adaptive and Reserve Adaptive Responses for Chromosomal Inversions in pKZ1 Mouse Prostrate: Hints on Mechanism
  Day, T.K., Hooker, A.M, Zeng, G., Grdina, D.J., Scott, B.R., and Sykes, P.J.
  
  
• 2005 Workshop:
  Inhibition of NFkB DNA Binding by Helenalin Abolishes the Induced Radioprotective Effect by Amifostine's Active Metabolite WR1065 in Human Microvascular Endothelial Cells
  Murley, J.S., Kataoka, Y., and Grdina, D.J.

Publications:

Murley, J.S., Nantajit, D., Baker, K.L., Kataoka, Y., Li, J.J., and Grdina, D.J. (2008) Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiation Research 169(5):495-505.

Murley, J.S., Kataoaka, Y., Baker, K.L., Diamond, A.M., Morgan, W.F., and Grdina, D.J. (2007) Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor α. Radiation Research 167(4):465-474.

Hooker, A.M., Day, T., Gridina, D.J., Bhat, M., and Sykes, P.J. (2006) Amifostine reduces chromosomal inversions pKZ1 spleen post X-irradiation. Environmental and Molecular Mutagenesis 47(6):429.

Kataoka, Y., Bindokas, V.P., Duggan, R.C., Murley, J.S., and Grdina, D.J. (2006) Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells. J. of Radiation Research 47(3-4):245-257.

Murley, J.S., Katakoa, Y., Baker, K.L., Diamond, A.M., Morgan, W.F., and Grdina, D.J. (2007) Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor α. Radiation Research 167:465-474.

Murley, J.S., Nantajit, D., Giometti, C., Diamond, A., Kataoka, Y., and Grdina, D.J. (2006) A persisitent thiol-induced MnSOD-mediated delayed cytoprotective effect in human microvascular endothelial cells (HMEC). Environmental and Molecular Mutagenesis 47(6):466.

Grdina, D.J., Murley, J.S., Kataoka, Y., Zhou, D., and Seed, T.M. (2005) Radiotherapeutic interactions. Extended Abstracts. Radiation Research 163:704-705.

Grdina, D.J., Murley, J.S., Kataoka, Y., and Epperly, W. (2002) Relationships between cytoprotection and mutation prevention by WR-1065. Military Medicine 167 Suppl:51-53.