Bobby Scott
Lovelace Biomedical & Environmental Research Institute
505-348-9470
E-mail: bscott@Lrri.org
Website: http://www.radiation-scott.org

• BIO-BASED RISK MODELING 03-20

Biological-Based Modeling of Low Dose Radiation Risks

Currently Funded Projects:

Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low-Dose, Low-Dose-Rate Exposure

Technical Abstracts:

• 2006 Workshop:
  Low-Dose/Dose-Rate Low LET Radiation Protects Us from Cancer
  Scott, B.R., and De Palma, J.D.
  
  Adaptive and Reserve Adaptive Responses for Chromosomal Inversions in pKZ1 Mouse Prostrate: Hints on Mechanism
  Day, T.K., Hooker, A.M, Zeng, G., Grdina, D.J., Scott, B.R., and Sykes, P.J.
  
• 2005 Workshop:
  NEOTRANS₃ Models for Low-Dose-Induced Stochastic Radiobiological Effects
  Scott, B.R.
  
• 2003 Workshop:
  A Protective Apoptosis-Mediated Process can be Turned on by Low-Dose, Low-LET Radiation
  Scott, B.R., Walker, D.M., and Walker, V.E.

• 2002 Workshop:
  Thresholds for Radiation-Induced Mutations and Neoplastic Transformation Could Arise from Apoptosis and Error-Free Repair
  Scott, B.R., Tesfaigzi, Y., Aden, J., Schöllnberger, H., and Walker, D.
  
  
• 2001 Workshop:
  Genomic Instability State Models for the Induction of Neoplastic Transformation by Low Radiation Doses
  Scott, B.R., Schöllnberger, H., Tesfaigzi, Y., Hanson, T.E., Osovets, S.V., Schmitt, C., and Aden, J.
  
  
• 2000 Modeling Workshop
  DOE Low Dose Radiation Research Program Workshop on Computer Modeling
  
  
• 1999 Workshop
  Advanced Computational Approaches for Characterizing Stochastic Cellular Responses to Low-Dose, Low-Dose-Rate Exposures
  Scott, B.R., Tesfaigzi, J., Schöllnberger, H., and Gerde, P.

Publications:

Calabrese, E.J., Bachmann, K.A., Bailer, J.A., Bolger, P.M., Borak, J., Cai, L., Cedergreen, N.,Cherian, M.G., Chiueh, C.C., Clarkson, T.W., Cook. R.R., Diamond, D.M., Doolittle, D.J., Scott, B.R., et. al. (2007) Biological stress response terminology: INtegrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicology and Applied Pharmacology 222:122-128.

Scott, B.R. (2007) Health risk evaluations foe ingestion exposure of humans to Polonium-210. Dose-Response 5:94-122.

Day, T.K., Zeng, G., Hooker, A.M., Bhat, M., Scott, B.R., Turner, D.R., and Sykes, P.J. (2006) Extremely low priming doses of X radiation induce an adaptive response for chromosomal inversions in pKZ1 mouse prostate. Radiat. Res.166(5):757-766.

Tokarskaya, Z.B., Zhuntova, G.V., Scott, B.R., Khokhryakov, V.F., Belayeva, Z.D., Vasilenko, E.K., and Syrchicov, V.A.(2006) Influence of alpha and gamma radiations and non-radiation risk factors on the incidence of malignant liver tumors among Mayak PA workers. Health Physics 91(4): 296-304.

Scott, B.R. (2006) Re: Risk of thyroid cancer after exposure to 131I in childhood. Journal of the National Cancer Institute 98(8):561.

Okladnikova, N.D., Scott, B.R., Tokarskaya, Z.B., Zhuntova, G.V, Khokhryakov, V.F., Syrchikov, V.A., and Grigoryeva, E.S. (2005) Chromosomal aberrations in lymphocytes of peripheral blood among Mayak facility workers who inhaled insoluble forms of 239PU. Radiation Protection Dosimetry 113(1):3-13.

Scott, B.R. (2005) Stochastic thresholds: A novel explanation of nonlinear dose-response relationships for stochastic radiobiological effects. Dose Response 3(4):547-567.

Scott, B.R. (2004) A biological-based model that links genomic instability, bystander, and adaptive response. Mutation Research 568:129-143.

Scott, B.R. (2004) Health risks from high-level radiation exposures from radiological weapons. Radiation Protection Management 21(6):9-25.

Aden, J. and Scott, B.R. (2003) Modeling variability and uncertainty associated with inhaled weapons-grade PuO2. Health Physics 84(6):726-736.

Scott, B.R. and Peterson, V.L. (2003) Risk estimates for deterministic health effects of inhaled weapons grade plutonium. Health Physics 85(3):280-293.

Scott, B.R., Walker, D.M., Tesfaigi, Y., Schöllnberger, H., and Walker, V. (2003) Mechanistic basis for nonlinear dose-response relationships for low-dose radiation-induced stochastic effects. Nonlinearity in Biology, Toxicology, and Medicine 1(1):93-122.

Schollnberger, H., Aden, J., and Scott, B.R. (2002) Respiratory tract deposition efficiencies: Evaluation of effects from smoke released in the Cerro Grande forest fire . Journal of Aerosol Medicine 15(4):387-399

Scott, B.R. and Schöllnberger, H. (2000) Introducing biological microdosimetry for ionizing radiation. Radiation Protection Dosimetry 91(4):377-384.

Presentations:

PSA Presentation, San Francisco, CA., Sept. 2005 "The LNT Hypothesis May Have Outlived Its Usefulness for Low-LET
Radiation."