Bruce N. Ames
bnames@uclink4.berkeley.edu
University of California, Berkeley
Website: Chori-org/bnameslab/bnames.html

Technical Abstracts:

• 2002 Workshop:
  Comparison of Low-Dose Radiation, Endogenous Oxidants, and Micronutrient Deficiencies through Analyses of DNA Damage and Cellular Responses. Courtemanche, C., Huang, A.C., Kerry, N., Ng, B. and Ames, B.N.
  
  
• 2001 Workhop:
  Comparison of DNA Damage Risk from Low-Dose Radiation and Folate Deficiency.
  Huang, A.C., Courtemanche, C., Kerry, N., Mashiyama, S.T., Fenech, M. and Ames, B.N.
  
  
• 1999 Workshop:
  Micronutrient Deficiency as a Radiation Mimic.
  Ames, B.N.

Publications:

Ames, B.N., Elson-Schwab, I., and Silver, E. (2002) High-dose vitamins stimulate variant enzymes with decreased coenzyme-binding affinity (increased Km): Relevance to genetic disease and polymorphisms. Am. J. Clin. Nutr. 75(4):616-658.

Atamna, H., Cheung, I., and Ames, B.N. (2002) A method for detecting a basic sites in living cells: Age-dependent changes in base excision repair. Proc. Natl. Acad. Sci., U.S.A. 97:686-691.

Atamna, H., Walter, P.B., and Ames, B.N. (2002) The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age. Arch. Biochem. Biophys. 397:345-353.

Hagen, T.M., Liu, J., Lykkesfeldt, J., Wehr, C.M., Ingersoll, R.T., Vinarsky, V., Bartholomew, J.C., and Ames, B.N. (2002) Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc. Natl. Acad. Sci., U.S.A. 99:1870-1875.

Liu, L., Atamna, H., and Ames, B.N. (2002) Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann. New York Acad. Sci. 959, (In press).

Walter, P.B., Knutson, M.D., Paler-Martinez, A., Lee, S., Xu, Y., Viteri, F.E., and Ames, B.N. (2002) Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc. Natl. Acad. Sci., U.S.A. 99:2264-2269.

Ames, B.N. (2001) DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat. Res. 475(1-2):7-20.

Atamna, H., Liu, J. and Ames, B.N. (2001) Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: relevance to aging. J. Biol. Chem. 276:48410-48416.

Crott, J.W., Mashiyama, S.T., Ames, B.N., and Fenech, M. (2001) Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA In vitro. Carcinogenesis 22:1019-1025.

Crott, J.W., Mashiyama, S.T., Ames, B.N., and Fenech, M. (2001) The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes In vitro. Cancer Epidemiol. Biomarkers Prev. 10:1089-1096

Mayr, C.A., Woodall, A.A., and Ames, B.N. (2001) DNA damage to sperm from micronutrient deficiency may increase the risk of birth defects and cancer in offspring. In: Preventative Nutrition: The Comprehensive Guide for Health Professionals. Bendich, A. and Deckelbaum, R.J., (Eds.). Totowa, NJ: Humana Press, p. 373-386.

Wallock, L.M., Tamura, T., Mayr, C.A., Johnston, K.E., Ames, B.N., and Jacob, R.A. (2001) Low seminal plasma folate is associated with low sperm density and number in smoking and nonsmoking men. Fertil. & Steril. 75:252-259.

Crott, J.W., Mashiyama, S.T., Ames, B.N., and Fenech, M.F. (2001) Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis 22(7):1019-1025.

Beckman, K.B., Saljoughi, S., Mashiyama, S.T., and Ames, B.N. (2000) A simpler, more robust method for the analysis of 8-oxoguanine in DNA. Free Radic. Biol. Med. 29:357-367.