Edwin H. Goodwin
goodwin_edwin_h@lanl.gov
Los Alamos National Laboratory

Newly Funded Projects:

Genomic Instability Induced by a Bystander Signal

Past Funded Projects:

Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment

Biological Effects of LowLevel Ionizing Radiation and Normal Oxidative Demage: The Same or Different?

Technical Abstracts:

• 2005 Workshop:
  Mechanisms of the Adaptive Response to Radiation
  Goodwin, E.H., Field, A., Sanders, C., Chen, D. and Kadhim, M.
  
  
• 2003 Workshop:
  The Dual Roles of DNA-PK in DSB Repair and Telomere Protection
  Goodwin, E.H., Bailey.S., Brenneman, M., Halbrook, J. and Nickoloff, J.
  
  Dysfunctional Mammalian Telomeres Join to Double-Strand Breaks
  Bailey, S.M., Goodwin, E.H., Williams, E. and Ullrich, R.L.
  
  
• 2002 Workshop:
  Telomere Dysfunction Contributes to the Radiation-Sensitive Phenotype of SCID.
  Goodwin, E.H. and Bailey, S.M.
  
  
• 2001 Workshop:
  Telomere Dysfunction and Radiation-Induced Chromosomal Instability. Goodwin, E.H. and Bailey, S.M.

Glutathione and Radiation Hormesis.
Goodwin, E.H. and Bailey, S.M

• 1999 Workshop:
  Genome Wide Gene Expression of LLIR and Biological Consequences.
  Chen, D.J., Rubin, E. and Goodwin, E.H.
  
  Biological Effects of Low Level Ionizing Radiation and Normal Oxidative Damage: The Same or Different?
  Goodwin, E.H.

Publications:

Bailey, S.M., Brenneman, M.A., and Goodwin, E.H. (2004) Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic, Acids Research, 32(12): 3743-3751.

Bailey, S.M., Cornforth, M.N., Ullrich, R.L., and Goodwin, E.H. (2004) Dysfunctional mammalian telomeres join with DNA double-strand breaks. DNA Repair 3:349-357.

Bailey, S.M., and Goodwin, E.H. (2004) DNA and telomeres: beginnings and endings. Cytogenic and Genome Research, 104(1-4): 109-115.

Kadhim, M.A., Moore, S.R., Goodwin, E.H. (2004) Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response. Mutation Research, 568: 21-32.

Donoh, G., Brenneman, M.A., Cui, T.X., Donoviel, D., Vogel, H., Goodwin, E.H., Chen, D.J., and Hasty, P. (2003) Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosome instability, and reduced life span in mice. Genes, Chromosomes, & Cancer 36: 317-331.

Cornforth, M.N., Bailey, S.M., and Goodwin, E.H. (2002) Dose response for chromosome aberrations produced in non-cycling primary human fibroblasts by alpha particles and by gamma rays delivered at sub-limiting low dose rates. Rad. Res. 158:43-53.

Bailey, S.M., Meyne, J., and Goodwin, E.H. (2001) Telomeres, DNA repair proteins and making ends meet. In: DNA damage and repair, Vol. 3, Nickoloff, J.A. and Hoekstra, M.F. (Eds.) Contemporary cancer research series. Humana Press. pp. 359-375.

Bailey, S.M., Cornforth, M.N., Kurimasa, A., Chen, D.J., and Goodwin, E.H. (2001) Strand-specific postreplicative processing of mammalian telomeres. Science 293:2462-2465.

Bailey, S.M., Meyne, J., Chen, D.J., Kurimasa, A., Li, G.C., Lehnert, B.E., and Goodwin, E.H. (1999) DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. PNAS 96(26):14899-14904.

Lehnert, B.E. and Goodwin, E.H. (1997) Extracellular factor(s) following exposure to a particles can cause sister chromatid exchanges in normal human cells. Cancer Research 57:2164-2171.

Narayanan, P.K., Goodwin, E.H., and Lehnert, B.E. (1997) a Particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Research 57:3963-3971.

Cornforth, M.N. and Goodwin, E.H. (1991) The dose-dependent fragmentation of chromatin in human fibroblasts by 3.5-MeV a particles from ²³⁸Pu: Experimental and theoretical considerations pertaining to single-track effects. Radiation Research 127:64-74.