Dec | Nov | Oct | Sep | Aug | Jul | Jun | May | Apr | Mar | Feb | Jan

Past Exposure to Densely Ionizing Radiation Leaves a Unique PermanentSignature in the Genome (2003) M. Prakash Hande, Tamara V. Azizova, CharlesR. Geard, Ludmilla E. Burak, Catherine R. Mitchell, Valentin F. Khokhryakov,Evgeny K. Vasilenko, and David J. Brenner, published by the University ofChicago Press, The American Society of Human Genetics. All rights reserved.72:1162-1170

Tony Brooks
tbrooks@tricity.wsu.edu

New Publications

Miller, J.H., Fan-Chiang, C-C.P., Straatsma, T.P., and Kennedy, M.A. (2003) 8-Oxyoguanine enhances bending of DNA that favors binding to glycosylases. J. Am. Chem. Soc. 125:6331-6336.

Meetings

The 34th Annual meeting of the Environmental Mutagen Society, "Environmental Mutagenesis: From Mechanisms to Risk Assessment," was held in Miami Beach Florida, May 10-14, 2003.

This meeting was attended by about 900 scientists. Radiation was one of the first environmental mutagens identified, and as the result of this, much of the thinking, problems and concerns that are present in the EMS society are similar to those being addressed by members of the radiation research community. A major concern for EMS is the shape of the dose-response curves following very low levels of exposure to known direct acting mutagens, i.e. agents that do not require metabolic activation to produce mutations. Such chemicals seem to have a mode of action similar to radiation.

The major session of interest to the DOE Low Dose Radiation Research Program was, "Potential Modifiers of Carcinogenesis at Low Doses," Chairpersons: R. Julian Preston, U.S. EPA and Antone L. Brooks, Washington State University. Presenters and titles follow:

There were several other presentations in this meeting that considered radiation as the agent and thus were important to the DOE Low Dose Research Program.

Abstracts for all of these papers are available in Environmental and Molecular Mutagenesis 41, No. 3 (2003). These can be provided to anyone interested by contacting Dr. Brooks.

A second meeting of interest to the DOE Low dose Radiation Research Program was the BELLE meeting: "Non-Linear Dose-Response Relationships in Biology, Toxicology and Medicine," held in Amherst, MA, May 28-30.

The thrust of this meeting was to discuss dose-response relationships for radiation and chemicals. There were sessions on General Principles, Radiation, BioMedical, Toxicology and Environmental Agents. The discussion revolved around hormesis. A definition of hormesis was given as: a compensatory biological process following a disruption in homeostasis. Dr. Ludwig E. Feinendegen was the moderator of the Radiation Session that ranged from risk assessment to modeling and discussions of the LNTH. The program for this meeting is found on this Website at: Proceedings from Meetings. I will be happy to address any questions about the meeting.

Meetings of Interest in the next 2 months

July 2003

Please let us know of additional important meetings related to the Biological Effects of Radiation.

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Tony Brooks
tbrooks@tricity.wsu.edu

News:

Dr. Metting organized and conducted a scientific review of the proposals from the call, Office of Science Notice 03-07 or Lab03-07 "Low Dose Radiation Research Program-Basic Research". DOE is currently evaluating the results of the review as they make funding decisions.

The Office of Biological and Environmental Research (OBER) of the Office of Science (SC), U.S. Department of Energy (DOE) has announced its interest in receiving applications for U.S. Department of Energy Office of Science Notice 03-20. "Low Dose Radiation Research Program-Biologically-Based Risk Modeling". This modeling is important to the success of the Low Dose Program as it will provide a biological archetype that will become the core source of data on the biological responses induced by low doses of radiation. Such an archetype will help define areas where additional research is needed. The date for pre-applications has passed, formal applications are due May 23, 2003. For complete information, see http://www.science.doe.gov/grants/Fr03-20.html. For additional information call Dr. Noelle Metting, 301-903-8309.

New Publications:

Morgan, W.F. (2003) Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-Induced genomic instability and bystander effects in vitro. Radiation Research 159:567-580.

Morgan, W.F. (2003) Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-Induced genomic instability and bystander effects in vivo, Clastogenic factors and transgenerational effects. Radiation Research 159:581-596.

Hande, M.P., Azizova, T.V., Geard, C.R., Burak, L.E., Mitchell, C.R., Khokhryakov, V.F., Vasilenko, E.K., and Brenner, D.J. (2003) Past exposure to densely-ionizing radiation leaves a unique permanent signature in the genome. American Journal of Human Genetics 72:1162-1170.

A comprehensive list of publications from the DOE Low Dose Program is updated each month from the "Notes from the Field" and is placed on this Web Site at "Project Publications". We have also initiated a search capability for these publications by topic. Try it and see if we have left any of your publications off any of the searches that should bring them up. If any publications that you have been involved in as part of the Low Dose Radiation Research Program are not on the site, please let us know and we will add them. Thanks

Meetings:

The National Council on Radiation Protection and Measurements conducted their 39th Annual meeting April 9-10, 2003. The title of the meeting was "Radiation Protection at the Beginning of the 21st Century-a Look Forward". The title of the meeting was very appropriate as the NCRP moves forward with a new director, Dr. Thomas Tenforde, and a new set of challenges. Elections were held at the meeting and the following new members were elected to six year terms. For 2001, Mary Austin Seymour, Thomas Borak, Frank Cucinotta, Andrew Grosovsky, Ann Kennedy, Jill Lipoti, Jack Miller, Edward Sickles, Lois Travis, Pat Zanzonico and for 2002, Jerrold Bushberg, John Cardella, Mary Clark, John Hirsfeld, Willian Morgan, Bruce Napier, Carl Paperiello, Daniel Strom. Congratulations!! The meeting provided a very broad overview of radiation standards and potential future directions. It covered the activities of, NCRP, ICRP, IAEA, Nuclear Energy Institute and federal regulatory agencies as well as providing a forum for stake-holders with environmental concerns. This meeting provided a very good update of not only the regulatory issues but also of public concerns, future directions and needs. The ex-president of the NCRP Dr. Charles B. Meinhold gave the Lauriston S. Taylor Lecture, "The Evolution of Radiation Protection: From Erythema to Genetic Risks to Risks of Cancer to?". This presentation provided a very good overview of the history of radiation protection and makes for good reading for anyone interested in how radiation protection standards developed.

We are aware of the following May/June meetings that may be of interest to those involved in the Low Dose Research Program.

May 2003

June 2003

Please let us know of additional important meetings.

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March, 2003
"Notes from the Field"

Tony Brooks
tbrooks@tricity.wsu.edu

News:

The new call for proposals, U.S. Department of Energy Office of Science Notice 03-20,"Low Dose Radiation Research Program-Biologically-Based Risk Modeling" will be of interest to many of you. The Office of Biological and Environmental Research (OBER) of the Office of Science (SC), U.S. Department of Energy (DOE) has announced its interest in receiving applications for participation in a biologically-based risk modeling exercise, for the purposes of developing and evaluating different modeling/prediction strategies. Pre-applications should be submitted by April 4, 2003, and formal applications are due May 23, 2003. For complete information, see http://www.science.doe.gov/grants/Fr03-20.html.

We want to congratulate Dr. Marvin Frazier, Director of OBER, who received a DOE award at the Human Genome Meeting in Santa Fe, New Mexico, March 30-April 2, 2003. The award was, "For sustained, outstanding leadership in genomics research that laid the groundwork for the Department of Energy's success in DNA sequencing at the Joint Genome Institute's Production Genomics Facility as part of the Human Genome Project and for initiating the Department's Genomes to Life Program, the next major step in biological research." Many of us also appreciate Marv's leadership and contributions to the Low Dose Radiation Research Program.

New Publications:

Leskov, K.S., Klokov, D.Y., Li, J. Kinsella, T.J., and Boothman, D.A. (2003) Synthesis and functional analyses of nuclear clusterin, a cell death protein. The Journal of Biological Chemistry 278(13):11590-11600.

Diedrich, M.J., Warters, R.L., and Grossman, D. (2002) Amifostine Aminothiols and protection of keratinocyte apoptosis and DNA damage. Journal of Investigative Dermatology 119:707-708.

Miller, J.H., Wilson, W.E., Lynch, D.J., Wei, K., Kurtulus, A., and Trease, H.E. (2002) Low-LET Microbeam Dosimetry. Radiation Research 158:377-378.

Wickliffe, J.K., Rodgers, B.E., Chesser, R.K., Phillips, C.J., Gaschak, S.P., and Baker, R.J. (2003) Mitochondrial DNA heteroplasmy in laboratory mice experimentally enclosed in the radioactive Chernobyl environment. Radiation Research 159:458-464.

A comprehensive list of publications from the DOE Low Dose Program is updated each month from the "Notes from the Field" and is placed on this Web Site at "Project Publications". We have also initiated a search capability for these publications by topic. Try it and see if we have left any of your publications off any of the searches that should bring them up. If any publications that you have been involved in as part of the Low Dose Radiation Research Program are not on the site, please let us know and we will add them. Thanks

Meetings:

The "Society of Toxicology" meeting was held in Salt Lake City from March 9-13. Drs. Richard Bull and Roger McClellan organized a session for this meeting, "Effects of Bystander Cells: Implications for Low-Dose Extrapolation of Chemical and Radiation-Induced Cancer Risk". This meeting applied information from the Low Dose Program to evaluating risks for low levels of chemical insult. This session was a good example of how information from the DOE Low Dose Radiation Research Program can interact with other aspects of risk assessment. The abstract and program for this session is listed in Proceedings from Meetings on this Web Site.

The April/May meetings, of interest to the Low Dose Research Program, which we are aware of are listed below:

May 2003

Please let us know of additional important meetings.

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February, 2003
"Notes from the Field"

Tony Brooks
tbrooks@tricity.wsu.edu

News:

The first news is that the deadline for the last call for proposals, Office of Science Notice 03-07 or Lab03-07 "Low Dose Radiation Research Program-Basic Research" has past, February 27, 2003. Dr. Metting has collected this group of proposals and is organizing a scientific review of them.

There is also a new call for proposals, U.S. Department of Energy Office of Science Notice 03-20. "Low Dose Radiation Research Program-Biologically-Based Risk Modeling" that should be of interest to many of you. The Office of Biological and Environmental Research (OBER) of the Office of Science (SC), U.S. Department of Energy (DOE) has announced its interest in receiving applications for participation in a biologically-based risk modeling exercise, for the purposes of developing and evaluating different modeling/prediction strategies. Pre-applications should be submitted by April 4, 2003, and formal applications are due May 23, 2003. For complete information, see http://www.science.doe.gov/grants/Fr03-20.html.

New Publications:

Redpath, J.L., Short, S.C., Woodcock, M. and Johnston, P.J. (2003) Low-dose reduction in transformation frequency compared to un-irradiated controls: The role of hyper-radiosensitivity to cell death. Radiation Research 159:422-436.

Bedford, J.S. (2003) Letters to the Editor Re: Target Theory and Timofeeff-Ressovsky. Radiation Research 159:135.

Dugan L.C., and Bedford, J.S. (2003) Are chromosomal instabilities induced by exposure of cultured normal human cells to low- or high-LET radiation? Radiation Research 159:301-311.

McAteer, K. and Kennedy, M.A. (2003) Force field dependence of NMR-based, restrained molecular dynamics of DNA structure calculations including an analysis of the influence of residual dipolar coupling restraints. Journal of Biomolecular Structure & Dynamics 20:487-506.

A comprehensive list of publications from the DOE Low Dose Program is updated each month from the "Notes from the Field" and is placed on this website at "Project Publications". If any publications that you have been involved in as part of the Low Dose Program are not on the site, please let us know and we will add them. Thanks

Meetings:

There was a very interesting meeting in Pompe Hall, Nagasaki University School of Medicine, Japan 21-22 February, 2003. This was part of an important event where Nagasaki University was designated as a "Center for Excellence (COE) of Radiation Life Science". Dr. Masami Watanabe is helping to organize this center and has participation from a number of Universities and Research Centers. The meeting held to start this new center of excellence was the "First Nagasaki Symposium of International Consortium for Medical Care of Hibakusha and Radiation Life Science in Nagasaki".

This meeting contained information that ranging from the major human radiation studies to some very good basic cell and molecular biology. The human studies reported included the follow-up of the Hiroshima and Nagasaki populations by the RERF and a review of the research that has been conducted at Nagasaki University on the A-bomb survivors. There were also several presentations given that involved evaluation of the human populations exposed by the Chernobyl accident. To complete the human epidemiological studies, two presentations were given on the health status of the radiation-exposed populations in Kazakhstan and Semipalatinsk.

A number of presentations were given on the progress that is being made on basic radiation biology and the development of a new microbeam in Japan. The final area of interest was how the universities and research institutions involved in this center of excellence program could work together to improve education in the field of radiation biology.

The final day of the meeting featured a number of additional talks on basic biology which provided a number of students and other investigators from the universities in Japan a chance to report on their research. The final session in the conference was a review of research challenges for low level radiation which described low level effects and current research being conducted by the DOE Low Dose Radiation Research Program. A complete copy of the program for this meeting is located on this website under "Proceedings from Meetings."

The March meetings that we are aware of are listed below.

Please let us know of additional important meetings.

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News:

Of special interest are the important deadlines for the 12th International Congress of Radiation Research, August 17-22 in Brisbane Australia. These deadlines are upon us. Travel Awards are available for young and senior investigators to attend the meeting. However, the deadline for these awards is February 7 so if you have not applied you need to quickly get a form into i.radford@pmci.unimelb.edu.au for potential support. The deadline for abstracts is March 10, for early registration May 16, and for Accommodation booking July 14, so keep these dates in mind. For more information see the linked web site at www.icrr2003.org.

New Publications:

A comprehensive list of publications from the DOE Low Dose Program is updated each month from the "Notes from the Field" and is on this Web Site. If any publications that you have been involved in as part of the Low Dose Program are not on the site, please let us know and we will add them. Thanks.

Meetings:

In January I attended the Gordon Research Conference on Radiation Oncology. Dr. Zvi Fuks (Memorial Sloan-Kettering) was chairman and Dr. Elizabeth Travis (MD Anderson Cancer Center) was vice-chair. This was a very well attended meeting with 120 scientists registered. There were 14 scientists from Laboratories funded by the Low Dose Radiation Research Program, many of whom gave presentations or posters. The emphasis of the discussions and presentations related to radiation therapy so most of the studies reported used very large radiation doses. However, the data and scientific advances being made in all the presentations could be related to radiation effects at both the cellular and molecular level of biological organization. There was discussion on the need to evaluate these mechanistic changes following lower levels of radiation exposure. A more complete report on this meeting is being prepared for my Web Site at: http://www.tricity.wsu.edu/faculty/brooks/Brooks_A.html and will be in place by the end of February.

The meetings we are aware of in February 2003 are:

Please let us know of additional important meetings.

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December 2002
"Notes from the Field"
Tony Brooks
tbrooks@tricity.wsu.edu

News:

We hope that you all had happy holidays in December and that the New Year is one that each of us will enjoy and accomplish much.

For those of you who are writing proposals for Program Notice 03-07, Low Dose Radiation Research Program - Basic Research, remember they are due by February 27.

The Department of Energy's Office of Science is providing a unique opportunity for outstanding graduate students to attend the Annual Meeting of Nobel Laureates in Lindau, German June 30-July 4, 2003 (with an orientation meeting June 27 in Washington D.C.). More information on the program is available at http://www.orau.gov/orise/edu/lindau2003. Additional questions can be addressed by Roland F. Hirsch at 301-903-9009 or through email at roland.hirsch@science.doe.gov.

Publications:

Extended Abstracts:

American Statistical Association Conference on Radiation and Health, Deerfield Beach, Florida, June 23-26:

A list of publications from the DOE Low Dose Program is updated each month from the "Notes from the Field" and is on this Web Site. If any publications that you have been involved in as part of the Low Dose Program are not on the site, please let us know and we will add them. Thanks.

Meetings:

None were reported or attended during the month of December. The Gordon Conference on Radiation Oncology: Molecular Mechanisms in the Response to Radiation is being held in Ventura CA January 26-31. If you are aware of other meetings please give us the information so that the results of the meetings can be shared.

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November, 2002
“Notes from the Field”
Tony Brooks
tbrooks@tricity.wsu.edu

News:

The new call for proposals is out. The details of the call are on this web site under the "What's New" section. The deadline for pre-applications was December 6, 2002 and the deadline for formal applications is February 27, 2003. If you missed the deadline for pre-applications and still want to be involved in the program call and discuss your potential proposal with Dr. Noelle Metting (301-903-8309) the DOE Low Dose Research Program director.

During November, I was able to spend time in Germany at GSF-National Research Center for Environment and Health in the Institute of Radiation Protection and in England at the Gray Laboratory and the Medical Research Council (MRC). All three of these locations provided research information and links to our web site. As part of the information gathering exercise, I was able to discuss the research being conducted and collect a nice set of recent reprints. A great deal of the research being conducted at these institutions is directly related to the work being conducted under the DOE Low Dose Research Program. I appreciated the time and energy that the staff invested to provide me with this information. Listings of the reprints that I got while on this trip will be posted on our web site and we can provide additional information as requested.

I was especially interested in the European policy that requires those who reach the ripe old age of 65 to retire. As I discussed this with Dudley Goodhead and Barry Michael, who are both rapidly storming down on this age, I realized that this policy results in great loss of scientific talent and corporate memory. What do we do with great scientists whose only sin is to live a long time and remain active in the field?

I hope all you U.S. folks had a happy Thanksgiving and an opportunity to remember those that are important to you.

Publications:

A list of publications from the DOE Low Dose Program are found on this Web Site. If any publications that you have been involved in as part of the Low Dose Program are not on the site, please let us know and we will add them. Thanks.

Meetings:

The 5th Annual John B. Little Symposium: "Cell signaling in Radiobiology and Carcinogenesis" was held November 1-2, 2002 at the Harvard School of Public Health. As usual, an exceptional group of speakers provided a state of the art review of the subject.

A meeting, "Biomarkers of exposure to low doses of Ionizing Radiation", was organized by Dr. Kanokporn Noy Rithidech at Kasetart University, Bangkok, Thailand. The meeting was funded by the Thai Ministry of University Affairs. Such meetings strengthen the academic capability of local universities and provide a bridge to research being conducted in other countries. This is to be a continuing effort with another meeting in Thailand in 2003.

Dr. Doug Boreham organized a meeting "Networking Radiation Sciences in Health, Safety and the Environment" at McMasters University, in Hamilton, ON, Canada November 25-26, 2002. This meeting was successful in mixing basic science with the nuclear industry, academia and government. It provided a good review and up-date of the biology of low dose radiation and explored how this information may impact standards in the future. There were seven scientists, which have received funding from the DOE Low Dose Radiation Research Program, who provided reviews of their areas of expertise. These reviews provided the scientific basis for the discussions that followed on the implications of the basic research on risk and standards.
There were also scientific presentations by other very good scientists not associated with the Low Dose Radiation Research program, as well as a series of posters from students from McMasters University. Several of these papers applied basic research observations to experimental animal systems to test how well the in vitro data predicted the response in vivo. These studies demonstrated adaptive responses for a number of endpoints that resulted in both a decreased tumor frequency and an extended life span. The meeting concluded with a series of panel discussions: Government Perspectives, Industrial Perspectives, Medical Perspectives in Low Dose Radiation Exposure, and Educational Perspectives. This meeting provided essential links between the basic science and the remainder of the scientific, regulatory and business community with concerns and needs related to radiation effects. If additional information is needed on this meeting please feel free to contact me or Dr.Doug Boreham. boreham@mcmaster.ca

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October, 2002
"Notes from the Field"
Tony Brooks

The month of October has been full of meetings and Website activity for me. The Website, http://lowdose.tricity.wsu.edu, is in the early stages of development and is changing daily. We appreciate any of your suggestions to improve it. The Program office has invited any of you that would like to link your personal/laboratory Website URLs to the Low Dose Website to provide that information to me at tbrooks@tricity.wsu.edu.

We continue to provide outreach by making presentations to interested groups. This month I gave presentations at the Tri-Cities Rotary Club and the Washington State Department of Ecology to bring them up to date on the new research that is being conducted in the DOE Low Dose Program. Please keep us posted if you would like to share your own involvement in scientific outreach activities.

Publications:

Cornforth, M.N., Greulich-Bode, K.M., Loucas, B.D., Arsuaga, J., Vazequz, M., Sachs, R.K., Bruckner, M., Molls, P., Hahnfeldts, L., Hlatky, L. and Brenner, D.J. (2002) Chromosomes are predominantly located randomly with respect to each other in interphase human cells. J. Cell Biol.159(2):237-244.

Guerreo, M., Stewart, R.D., Wang, J., and Li, K.A. (2002) Equivalence of linear-quadratic and two-lesion kinetic models. Phys. Med. Biol. 46(17): 3197-3209.

Toburen, L.H., Shinpaugh, J.L., and Justiniano, E.L.B. (2002) Modeling interaction cross sections for intermediate and low energy ions.Radiat. Prot. Dosimetry 99:49-51.

Toburen, L.H., and Shinpaugh, J.L., Laboratory data needs and applications for assessing radiation effects in biological materials. In: Atomic and Molecular Data and Their Applications, eds. David R. Schultz, Predrag S. Krstic, Fay Ownby, Conference Proceedings 636, American Institute of Physics, Melville, New York (2002) pp. 23-32.

A list of publications from the DOE Low Dose Radiation Research Program are found on our Website. If you have any corrections to this list, please let us know.

A meeting October 4, 2002, in Paris France, under the direction of Andre Maisseu, was held to organize the "Low Rad" Constitutive General Assembly. At this conference, a new journal "International Journal of Low Radiation" was established. Those interested in additional materials on this organization and journal can contact Dr. Maisseu at AMAISSEU@cogema.fr.

The "World Space Congress" was held in Houston Texas, 10-19 October 2002. This was a very large meeting with many of the sessions focused on space travel. Of particular interest to me was the session on "Biodosimetry, Biomarkers and Late Stochastic Effects of Space Radiation", a joint COSPAR/IAC event. This session discussed a wide range of subjects related to the health effects of the radiation environment that will exist during space travel.
At this conference, the proper use of biomarkers was reviewed and Eleanor Blakely and me. There were several presentations on the induction of chromosome damage by high Z particles. Mike Cornforth noted that chromosome painting techniques, such as SKY or mFISH, make it possible to detect aberrations involving many different chromosomes. These techniques have been shown to provide markers of exposure to high-LET radiation. The dose-response relationships for the induction of complex aberrations were very different for low and high-LET radiation. For low-LET radiation there were very few complex aberrations produced at low doses, while the high-LET radiation produced these aberrations at all doses evaluated. Thus, chromosome aberrations can make a good marker for radiation exposure type. Other researchers tried similar studies, using either standard staining techniques or staining with only two or three different color FISH, but were not able to demonstrate the differences reported by Mike.

There were several papers presented describing biological changes induced by very large radiation doses. These types of presentations and information may be useful in understanding some biological phenomena, but are of limited used in evaluating the hazards associated with space travel.

Several papers regarding models of radiation interaction with cells were presented at this Congress, including one by members of the low dose research team, Ed Goodwin and Mike Cornforth. This paper "A computer simulation of chromosomal instability" showed the role of cell division and survival on genomic instability.

I would be happy to provide additional information on this meeting to anyone interested.

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Iyer, R., and Lehnert, B.E. (2002) Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells. Mutation Research: Fundamental Molecular Mechanisms of Mutation 503:1-9.

Iyer, R., and Lehnert, B.E. (2002) Alpha particle-induced increases in the radio-resistance of normal human bystander cells. Radiation Research 157:3-7.

Goldberg, Z., and Lehnert, B.E. (2002) Radiation-induced effects in unirradiated cells: A review and implications in cancer. International Journal of Oncology 21(2):337-349.

Lehnert, B.E., and Iyer, R. (2002) Exposure to low level chemicals and ionizing radiation: Reactive oxygen species and cellular pathways. Human Experimental Toxicology B21:B65-69.

Larry Thompson, "How DNA Repair and Checkpoint Pathways Minimize Genetic Damage from Ionizing Radiation"

Antone L. Brooks, "The role of Microbeams in Radiation Biology"

Noelle Metting	Moderator
Joel Bedford	Chromosome Damage
Sally A. Amundson	Gene Expression
David Boothman	Protein Expression
Eric Hall, William F. Morgan	Bystander Effects
Antone L. Brooks	Biological Dosimetry
Mary-Helen Barcellos-Hoff	Cellular/Tissue Effects
Howard L. Liber	Mutation and Carcinogenesis

 

Brenner, D.J. and Sachs, R.K. (2002) Do low dose-rate bystander effects influence domestic radon risks? Int. J. Radiat. Biol. 78: 593-604.

Georgakilas, A.G., Bennett, P.V., Sutherland, B.M. (2002) High efficiency detection of bi-stranded abasic clusters in gamma-irradiated DNA by putrescine. Nucleic Acid Research 30(13):2800-2808.

Rydberg, B., Heilbronn, L., Holley, W.R., Lobrich, M., Zeitlin, C., Chatterjee, A., Cooper, P.K. (2002) Spatial Distribution and yield of DNA double-strand breaks induced by 3-7 MeV helium ions in human fibroblasts. Radiation Research 158:32-42.

Cornforth, M.N., Bailey, S.M., Goodwin, E.H. (2002) Dose response for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles and by gamma rays delivered at sub-limiting low dose rates. Radiation Research 158:43-53.

Parvin, B., Yang, Q., Fontenay, G., Barcellos-Hoff, M.H. (2002) Biosig: An Imaging Bioinformatic System for Studying Protenomics, IEEE Press, Piscataway, N.J. pp. 1-17.

U.S. Food and Drug Administration,
National Institute of Occupational Health and Safety,
Agency for Disease Registry and Emergency Response,
U.S. Environmental Protection Agency,
U.S. Department of Energy,
National Institute of Environmental Health Sciences
National Cancer Institute.

Eric Hall, "Bystander effects: indirectly mediated cellular responses"
David Hoel, "Risk assessment at low doses of radiation"
Leslie Redpath, "Adaptive responses"
William Morgan, "Genomic/chromosomal instabilities associated with radiation exposure"
Mary Helen Barcellos-Hoff, "Tissue factors that determine carcinogenic responses in vivo"

"Critical elements of risk assessment: What do we need to know?"
"Causal linkages: Key events and what makes a response adverse?"
"Concepts of dose-response: How to couple dose-response relationships across levels of biological organization"
"Dealing with variability and uncertainty as a matter of policy: The impact of generalization"
"Role of scientific consensus: What certainty is needed for regulatory policy"

Adaptive Response: David Brenner, Matthew Coleman, Doug Boreham
Genomic Instability: Robert Ullrich,
Selection Processes: Sally Amundson, Aloke Chatterjee, David Boothman
Genetic Sensitivity: Antone Brooks, Rob Stewart

 

Vance, M.M., Baulch, J.E., Raabe, O.G., Wiley, L.M. and Overstreet, J.W. (2002) "Cellular reprogramming of the F3 mouse with parental F0 radiation history", International Journal of Radiation Biology 78(6):513-527.

Nimura, Y., Ismail, S.M., Kuriman, A., Chen, D.J., and Stevens, C.W. (2002) "DNA-PK and ATM are Required for Radiation-Enhanced Integration" Radiation Research 157:562-567.

Sutherland, B.M., Bennett, P.V., Sutherland, J.C., and Laval, J. (2002) "Clustered DNA Damages Induced by X-rays in Human Cells" Radiation Research 157:611-616.

H. Schollnberger, M.G. Menache, Rod Stewart, W. Hofmann, "Impact of Cellular defense mechanisms and bystander effects on a multi-stage carcinogenesis model"

B.R. Scott, D.M. Walker, V. Walker, J. Aden, Y. Tesfaigzi, "Low-Dose Protective Mechanisms: Implications for Risk Assessment"